A Miniature pH Sensor in a Subcutaneous Injection Needle for Biofluid Sensing

IF 2.2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC IEEE Sensors Letters Pub Date : 2024-09-04 DOI:10.1109/LSENS.2024.3454486

Khengdauliu Chawang;Sen Bing;Jon Stellar;J.-C. Chiao

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Abstract

The pH value in bodily fluids is a crucial diagnostic marker. Conventional glass-rod pH sensors display reliability in aqueous solutions, but the pH-sensitive glass membrane makes them prone to inaccuracies in viscous solutions due to elevated junction potentials and bulky design hinders miniaturization. To overcome this issue, this work introduces a new pH sensor design and fabrication that enables miniaturization and reliability in aqueous and viscous solutions and facilitates insertion into a needle for in vivo monitoring. Utilizing a printing technique for the application of iridium oxide (IrOx) and silver/silver chloride coating on a single flexible polyimide substrate offers cost-effectiveness and production scalability. The sensor then is tailored with a sharp blade to a narrow strip that fits into a 20-gauge needle. The electrochemical measurements demonstrate that electrodes produced through this method demonstrate an accuracy of up to 0.1 pH within a narrow pH range (7.35–7.45) in buffer solutions and real human serum tests.

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用于生物流体传感的皮下注射针头微型 pH 传感器

体液中的 pH 值是重要的诊断指标。传统的玻璃棒式 pH 传感器在水溶液中表现可靠，但对 pH 值敏感的玻璃膜使其在粘稠溶液中容易因交界电位升高而出现误差，而且笨重的设计也阻碍了传感器的微型化。为了克服这个问题，这项研究介绍了一种新的 pH 传感器设计和制造方法，它能实现微型化，在水溶液和粘稠溶液中都能保持可靠性，并且便于插入针头进行体内监测。利用印刷技术将氧化铱（IrOx）和银/氯化银涂层应用于单个柔性聚酰亚胺基底，具有成本效益和生产可扩展性。然后用锋利的刀片将传感器裁剪成适合 20 号针头的窄条。电化学测量结果表明，在缓冲溶液和实际人体血清测试中，用这种方法生产的电极在较窄的 pH 值范围（7.35-7.45）内的精度可达 0.1pH。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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