Metabolic Flux Modeling in Marine Ecosystems

IF 14.3 1区 地球科学 Q1 GEOCHEMISTRY & GEOPHYSICS Annual Review of Marine Science Pub Date : 2024-09-11 DOI:10.1146/annurev-marine-032123-033718
Helen Scott, Daniel Segrè
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Abstract

Ocean metabolism constitutes a complex, multiscale ensemble of biochemical reaction networks harbored within and between the boundaries of a myriad of organisms. Gaining a quantitative understanding of how these networks operate requires mathematical tools capable of solving in silico the resource allocation problem each cell faces in real life. Toward this goal, stoichiometric modeling of metabolism, such as flux balance analysis, has emerged as a powerful computational tool for unraveling the intricacies of metabolic processes in microbes, microbial communities, and multicellular organisms. Here, we provide an overview of this approach and its applications, future prospects, and practical considerations in the context of marine sciences. We explore how flux balance analysis has been employed to study marine organisms, help elucidate nutrient cycling, and predict metabolic capabilities within diverse marine environments, and highlight future prospects for this field in advancing our knowledge of marine ecosystems and their sustainability.
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海洋生态系统代谢通量建模
海洋新陈代谢是一个复杂的、多尺度的生化反应网络集合体,蕴藏在无数生物体的内部和边界之间。要从数量上了解这些网络是如何运作的,就需要有数学工具,能够从硅学角度解决每个细胞在现实生活中面临的资源分配问题。为实现这一目标,新陈代谢的计量建模(如通量平衡分析)已成为揭示微生物、微生物群落和多细胞生物中错综复杂的新陈代谢过程的强大计算工具。在此,我们将概述这种方法及其在海洋科学中的应用、未来前景和实际考虑因素。我们将探讨如何利用通量平衡分析来研究海洋生物、帮助阐明养分循环和预测不同海洋环境中的代谢能力,并强调这一领域在促进我们对海洋生态系统及其可持续性的了解方面的未来前景。
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来源期刊
Annual Review of Marine Science
Annual Review of Marine Science 地学-地球化学与地球物理
CiteScore
33.60
自引率
0.60%
发文量
40
期刊介绍: The Annual Review of Marine Science, published since 2009, offers a comprehensive overview of the field. It covers various disciplines, including coastal and blue water oceanography (biological, chemical, geological, and physical), ecology, conservation, and technological advancements related to the marine environment. The journal's transition from gated to open access through Annual Reviews' Subscribe to Open program ensures that all articles are available under a CC BY license, promoting wider accessibility and dissemination of knowledge.
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