Sleep debt-induced anxiety and addiction to substances of abuse: A narrative review

IF 3.3 3区心理学 Q1 BEHAVIORAL SCIENCES Pharmacology Biochemistry and Behavior Pub Date : 2024-09-10 DOI:10.1016/j.pbb.2024.173874

Aline Ostos-Valverde , Andrea Herrera-Solís , Alejandra E. Ruiz-Contreras , Mónica Méndez-Díaz , Oscar E. Prospéro-García

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Abstract

Substance Use Disorder (SUD) has been conceptualized as an outcome of a dysregulated reward system. However, individuals with SUD suffer from anxiety with an intensity depending on the abstinence period length. This review discusses the role of anxiety as a major contributor to the initiation and perpetuation of SUD, and its dependence on an up-regulated defense-antireward system. In addition, it is discussed that sleep debt, and its psychosocial consequences, promote anxiety, contributing to SUD generation and maintenance. Healthy sleep patterns can be disrupted by diverse medical conditions and negative psychosocial interactions, resulting in accumulated sleep debt and anxiety. Within this narrative review, we discuss the interplay between the motivation-reward and defense-antireward systems, framing the progression from recreational drug use to addiction. This interplay is nuanced by sleep debt-induced anxiety and its psychosocial consequences as contributory vulnerability factors in the genesis of addiction.

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睡眠债务引发的焦虑和滥用药物成瘾：叙述性综述

药物滥用障碍（SUD）被认为是奖赏系统失调的结果。然而，患有药物滥用症的人也会焦虑，焦虑的强度取决于戒断期的长短。本综述讨论了焦虑作为导致药物依赖性失调症发生和持续的主要因素的作用，以及焦虑对上调的防御-反奖赏系统的依赖性。此外，还讨论了睡眠债务及其社会心理后果会促进焦虑，从而导致药物滥用的产生和维持。健康的睡眠模式可能会被各种疾病和负面的社会心理互动所破坏，从而导致累积的睡眠债务和焦虑。在这篇叙述性综述中，我们讨论了动机-奖赏系统和防御-反奖赏系统之间的相互作用，以及从娱乐性吸毒到成瘾的发展过程。睡眠债务引起的焦虑及其社会心理后果是导致药物成瘾的易感因素，这两者之间的相互作用是微妙的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacology Biochemistry and Behavior 医学-行为科学

CiteScore

6.40

自引率

2.80%

发文量

122

审稿时长

38 days

期刊介绍： Pharmacology Biochemistry & Behavior publishes original reports in the areas of pharmacology and biochemistry in which the primary emphasis and theoretical context are behavioral. Contributions may involve clinical, preclinical, or basic research. Purely biochemical or toxicology studies will not be published. Papers describing the behavioral effects of novel drugs in models of psychiatric, neurological and cognitive disorders, and central pain must include a positive control unless the paper is on a disease where such a drug is not available yet. Papers focusing on physiological processes (e.g., peripheral pain mechanisms, body temperature regulation, seizure activity) are not accepted as we would like to retain the focus of Pharmacology Biochemistry & Behavior on behavior and its interaction with the biochemistry and neurochemistry of the central nervous system. Papers describing the effects of plant materials are generally not considered, unless the active ingredients are studied, the extraction method is well described, the doses tested are known, and clear and definite experimental evidence on the mechanism of action of the active ingredients is provided.