Javier Ramos-Soriano, Maisie Holbrow-Wilshaw, Eliza Hunt, Y. Jennifer Jiang, Pablo Penalver, Juan Carlos Morales, M. Carmen Galan
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引用次数: 0
Abstract
Novel strategies against parasitic infections are of great importance. Here we describe a G4 DNA ligand with subnanomolar antiparasitic activity against T. brucei and a remarkable selectivity index (IC50 MRC-5/T. brucei) of 2285-fold. We also correlate the impact of small structural changes to G4 binding activity and antiparasitic activity.
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