Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges

IF 40.8 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Signal Transduction and Targeted Therapy Pub Date : 2024-09-13 DOI:10.1038/s41392-024-01936-8
Yunlong Shan, Mengying Zhang, Enxiang Tao, Jing Wang, Ning Wei, Yi Lu, Qing Liu, Kun Hao, Fang Zhou, Guangji Wang
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Abstract

Over the past two decades, mesenchymal stem/stromal cell (MSC) therapy has made substantial strides, transitioning from experimental clinical applications to commercial products. MSC therapies hold considerable promise for treating refractory and critical conditions such as acute graft-versus-host disease, amyotrophic lateral sclerosis, and acute respiratory distress syndrome. Despite recent successes in clinical and commercial applications, MSC therapy still faces challenges when used as a commercial product. Current detection methods have limitations, leaving the dynamic biodistribution, persistence in injured tissues, and ultimate fate of MSCs in patients unclear. Clarifying the relationship between the pharmacokinetic characteristics of MSCs and their therapeutic effects is crucial for patient stratification and the formulation of precise therapeutic regimens. Moreover, the development of advanced imaging and tracking technologies is essential to address these clinical challenges. This review provides a comprehensive analysis of the kinetic properties, key regulatory molecules, different fates, and detection methods relevant to MSCs and discusses concerns in evaluating MSC druggability from the perspective of integrating pharmacokinetics and efficacy. A better understanding of these challenges could improve MSC clinical efficacy and speed up the introduction of MSC therapy products to the market.

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间充质干细胞在转化挑战中的药代动力学特征
在过去二十年里,间充质干细胞/间质干细胞疗法取得了长足进步,从实验性临床应用过渡到商业产品。间充质干细胞疗法在治疗急性移植物抗宿主病、肌萎缩性脊髓侧索硬化症和急性呼吸窘迫综合征等难治性和危重症方面大有可为。尽管最近在临床和商业应用方面取得了成功,但间叶干细胞疗法在用作商业产品时仍面临挑战。目前的检测方法存在局限性,导致间充质干细胞在患者体内的动态生物分布、在损伤组织中的持久性和最终归宿不明确。明确间充质干细胞的药代动力学特征与其治疗效果之间的关系对于患者分层和制定精确的治疗方案至关重要。此外,开发先进的成像和跟踪技术对于应对这些临床挑战也至关重要。本综述全面分析了间充质干细胞的动力学特性、关键调控分子、不同命运和检测方法,并从药代动力学和疗效相结合的角度讨论了评估间充质干细胞可药用性的问题。更好地理解这些挑战可以提高间充质干细胞的临床疗效,加快间充质干细胞治疗产品的上市速度。
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来源期刊
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
44.50
自引率
1.50%
发文量
384
审稿时长
5 weeks
期刊介绍: Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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