{"title":"Antifungal Mechanism of Natural Products Derived from Plants: A Review","authors":"Nanbiao Long, Fang Li","doi":"10.1177/1934578x241271747","DOIUrl":null,"url":null,"abstract":"Fungal resistance to the limited existing antifungal agents has become a considerable public health problem in the past few decades. However, natural products with multiple bioactivities are important sources for developing new therapeutic agents against fungi. Consequently, there is an urgent need to grasp the antifungal mechanism of natural products. In this review, the primary antifungal mechanisms of natural products derived from plants, including targeting the cell wall, cell membrane, mitochondria, biofilm and other mechanisms, are elaborated. This article critically describes the compounds with high antifungal activity, revealing opportunities for future research such as clinical trials or utilization as environmental disinfectants.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"16 1","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Communications","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/1934578x241271747","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Fungal resistance to the limited existing antifungal agents has become a considerable public health problem in the past few decades. However, natural products with multiple bioactivities are important sources for developing new therapeutic agents against fungi. Consequently, there is an urgent need to grasp the antifungal mechanism of natural products. In this review, the primary antifungal mechanisms of natural products derived from plants, including targeting the cell wall, cell membrane, mitochondria, biofilm and other mechanisms, are elaborated. This article critically describes the compounds with high antifungal activity, revealing opportunities for future research such as clinical trials or utilization as environmental disinfectants.
期刊介绍：
Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products.
Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products.
Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products.
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