Selective Voltammetric Determination of Dopamine Using a Palladium Particle-Modified Electrode with Molecularly Imprinted Nicotinamide Polymer

IF 1 4区化学 Q4 CHEMISTRY, ANALYTICAL Journal of Analytical Chemistry Pub Date : 2024-09-03 DOI:10.1134/S1061934824700680

L. G. Shaidarova, I. A. Chelnokova, D. Y. Khairullina, Y. A. Leksina, H. C. Budnikov

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Abstract

A method was developed to fabricate a glassy carbon electrode with electrodeposited palladium particles and a molecularly imprinted polymer derived from nicotinamide. This approach enables the determination of dopamine in the presence of structurally related compounds. The incorporation of a polymer featuring specific recognition sites tailored to the template molecule significantly enhanced the sensitivity and selectivity of dopamine detection. The immobilization of palladium particles on the electrode surface further improved the selectivity of voltammetric dopamine determination, even in the presence of adrenaline and noradrenaline, which exhibited a 200 mV difference in oxidation peak potentials. The analytical signal showed a linear bilogarithmic dependence on dopamine concentration within the range 5.0 × 10^–9 to 5.0 × 10^–3 M. This method was successfully applied to an analysis of urine samples, demonstrating its practical utility in real-world applications.

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使用分子印迹烟酰胺聚合物的钯粒子修饰电极选择性伏安法测定多巴胺

摘要研究人员开发了一种方法，用电沉积钯颗粒和烟酰胺分子印迹聚合物制造玻璃碳电极。这种方法可以在存在结构相关化合物的情况下测定多巴胺。聚合物具有针对模板分子定制的特定识别位点，这种聚合物的加入大大提高了多巴胺检测的灵敏度和选择性。在电极表面固定钯颗粒进一步提高了伏安法测定多巴胺的选择性，即使在肾上腺素和去甲肾上腺素存在的情况下也是如此，这两种物质的氧化峰电位相差 200 mV。在 5.0 × 10-9 到 5.0 × 10-3 M 的范围内，分析信号与多巴胺浓度呈线性双对数依赖关系。

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来源期刊

Journal of Analytical Chemistry 化学-分析化学

CiteScore

2.10

自引率

9.10%

发文量

146

审稿时长

13 months

期刊介绍： The Journal of Analytical Chemistry is an international peer reviewed journal that covers theoretical and applied aspects of analytical chemistry; it informs the reader about new achievements in analytical methods, instruments and reagents. Ample space is devoted to problems arising in the analysis of vital media such as water and air. Consideration is given to the detection and determination of metal ions, anions, and various organic substances. The journal welcomes manuscripts from all countries in the English or Russian language.