Exploring Gender Differences in the Association Between TyG Index and COPD: A Cross-Sectional Study from NHANES 1999-2018

IF 2.8 3区医学 Q1 Medicine International Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-09-04 DOI:10.2147/copd.s473089

Jun Guo, Jie Yang, Jinghua Wang, Wei Liu, Yingjie Kang, Zhi Li, Chen Hao, Shuai Qi

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Abstract

Purpose: This study examined gender differences in the association of Triglyceride-Glucose (TyG) index with the prevalence of chronic obstructive pulmonary disease (COPD), particularly in a non-diabetic population.
Methods: The study leveraged data from the National Health and Nutrition Examination Survey (NHANES), spanning from 1999 to 2018, with a cohort of 23,456 participants. Logistic regression and restricted cubic spline analyses were employed to explore the relationship between the TyG index and COPD prevalence.
Results: Statistical analyses revealed a significant positive association between the TyG index and COPD prevalence among non-diabetic women after adjustment for all covariates (OR=1.50; 95% CI, 1.08– 2.08), supported by a linear relationship (P for non-linearity=0.298). No equivalent significant association was found in non-diabetic men (OR=1.00; 95% CI, 0.67– 1.48). Within the diabetic group, the TyG index did not show a significant association with COPD prevalence, regardless of gender.
Conclusion: Our study reveals a significant positive correlation between the TyG index and COPD prevalence in the non-diabetic population, marked by notable gender differences.

Keywords: TyG index, insulin resistance, chronic obstructive pulmonary disease, cross-sectional study

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探究 TyG 指数与慢性阻塞性肺病之间的性别差异：1999-2018 年 NHANES 跨部门研究

目的：本研究探讨了甘油三酯-葡萄糖（TyG）指数与慢性阻塞性肺病（COPD）患病率之间的性别差异，尤其是在非糖尿病人群中：该研究利用了美国国家健康与营养调查（NHANES）的数据，时间跨度为 1999 年至 2018 年，共有 23456 名参与者。研究采用逻辑回归和限制性立方样条分析来探讨TyG指数与慢性阻塞性肺病患病率之间的关系：统计分析显示，在对所有协变量进行调整后，非糖尿病女性的TyG指数与慢性阻塞性肺病患病率之间存在显著的正相关关系（OR=1.50；95% CI，1.08- 2.08），且两者之间存在线性关系（非线性P=0.298）。在非糖尿病男性中没有发现同等重要的关联（OR=1.00；95% CI，0.67- 1.48）。在糖尿病组中，无论性别如何，TyG 指数与慢性阻塞性肺病发病率均无显著关联：结论：我们的研究显示，在非糖尿病人群中，TyG 指数与慢性阻塞性肺病患病率之间存在明显的正相关，且性别差异明显：TyG指数胰岛素抵抗慢性阻塞性肺病横断面研究

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来源期刊

International Journal of Chronic Obstructive Pulmonary Disease RESPIRATORY SYSTEM-

CiteScore

5.10

自引率

10.70%

发文量

372

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals