George Oliveira Barros;José Nathan Andrade Muller da Silva;Henrique Machado de Sousa Proença;Stanley Almeida Araújo;David Campos Wanderley;Luciano Rebouças de Oliveira;Washington Luis Conrado Dos-Santos;Angelo Amancio Duarte;Flavio de Barros Vidal
{"title":"Enhancing Podocyte Degenerative Changes Identification With Pathologist Collaboration: Implications for Improved Diagnosis in Kidney Diseases","authors":"George Oliveira Barros;José Nathan Andrade Muller da Silva;Henrique Machado de Sousa Proença;Stanley Almeida Araújo;David Campos Wanderley;Luciano Rebouças de Oliveira;Washington Luis Conrado Dos-Santos;Angelo Amancio Duarte;Flavio de Barros Vidal","doi":"10.1109/JTEHM.2024.3455941","DOIUrl":null,"url":null,"abstract":"Podocyte degenerative changes are common in various kidney diseases, and their accurate identification is crucial for pathologists to diagnose and treat such conditions. However, this can be a difficult task, and previous attempts to automate the identification of podocytes have not been entirely successful. To address this issue, this study proposes a novel approach that combines pathologists’ expertise with an automated classifier to enhance the identification of podocytopathies. The study involved building a new dataset of renal glomeruli images, some with and others without podocyte degenerative changes, and developing a convolutional neural network (CNN) based classifier. The results showed that our automated classifier achieved an impressive 90.9% f-score. When the pathologists used as an auxiliary tool to classify a second set of images, the medical group’s average performance increased significantly, from \n<inline-formula> <tex-math>$91.4\\pm 12.5$ </tex-math></inline-formula>\n% to \n<inline-formula> <tex-math>$96.1\\pm 2.9$ </tex-math></inline-formula>\n% of f-score. Fleiss’ kappa agreement among the pathologists also increased from 0.59 to 0.83. Conclusion: These findings suggest that automating this task can bring benefits for pathologists to correctly identify images of glomeruli with podocyte degeneration, leading to improved individual accuracy while raising agreement in diagnosing podocytopathies. This approach could have significant implications for the diagnosis and treatment of kidney diseases. Clinical impact: The approach presented in this study has the potential to enhance the accuracy of medical diagnoses for detecting podocyte abnormalities in glomeruli, which serve as biomarkers for various glomerular diseases.","PeriodicalId":54255,"journal":{"name":"IEEE Journal of Translational Engineering in Health and Medicine-Jtehm","volume":"12 ","pages":"635-642"},"PeriodicalIF":3.7000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10675352","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Journal of Translational Engineering in Health and Medicine-Jtehm","FirstCategoryId":"5","ListUrlMain":"https://ieeexplore.ieee.org/document/10675352/","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Podocyte degenerative changes are common in various kidney diseases, and their accurate identification is crucial for pathologists to diagnose and treat such conditions. However, this can be a difficult task, and previous attempts to automate the identification of podocytes have not been entirely successful. To address this issue, this study proposes a novel approach that combines pathologists’ expertise with an automated classifier to enhance the identification of podocytopathies. The study involved building a new dataset of renal glomeruli images, some with and others without podocyte degenerative changes, and developing a convolutional neural network (CNN) based classifier. The results showed that our automated classifier achieved an impressive 90.9% f-score. When the pathologists used as an auxiliary tool to classify a second set of images, the medical group’s average performance increased significantly, from
$91.4\pm 12.5$
% to
$96.1\pm 2.9$
% of f-score. Fleiss’ kappa agreement among the pathologists also increased from 0.59 to 0.83. Conclusion: These findings suggest that automating this task can bring benefits for pathologists to correctly identify images of glomeruli with podocyte degeneration, leading to improved individual accuracy while raising agreement in diagnosing podocytopathies. This approach could have significant implications for the diagnosis and treatment of kidney diseases. Clinical impact: The approach presented in this study has the potential to enhance the accuracy of medical diagnoses for detecting podocyte abnormalities in glomeruli, which serve as biomarkers for various glomerular diseases.
期刊介绍:
The IEEE Journal of Translational Engineering in Health and Medicine is an open access product that bridges the engineering and clinical worlds, focusing on detailed descriptions of advanced technical solutions to a clinical need along with clinical results and healthcare relevance. The journal provides a platform for state-of-the-art technology directions in the interdisciplinary field of biomedical engineering, embracing engineering, life sciences and medicine. A unique aspect of the journal is its ability to foster a collaboration between physicians and engineers for presenting broad and compelling real world technological and engineering solutions that can be implemented in the interest of improving quality of patient care and treatment outcomes, thereby reducing costs and improving efficiency. The journal provides an active forum for clinical research and relevant state-of the-art technology for members of all the IEEE societies that have an interest in biomedical engineering as well as reaching out directly to physicians and the medical community through the American Medical Association (AMA) and other clinical societies. The scope of the journal includes, but is not limited, to topics on: Medical devices, healthcare delivery systems, global healthcare initiatives, and ICT based services; Technological relevance to healthcare cost reduction; Technology affecting healthcare management, decision-making, and policy; Advanced technical work that is applied to solving specific clinical needs.