Stable and biocompatible multivalent polymer-grafted gold nanorods for enhanced photothermal antibacterial therapy

IF 2.7 3区 化学 Q2 POLYMER SCIENCE Journal of Applied Polymer Science Pub Date : 2024-09-04 DOI:10.1002/app.56230
Lin Mei, Zhimin Liu, Yanmei Shi, Xiangyun Zhang
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Abstract

Near-infrared laser-activated gold nanorods (AuNRs) with excellent photothermal property and tunable surface functionalization are considered as an ideal platform for biomedical applications. However, bare AuNRs have cytotoxicity against normal cells and are prone to agglomeration during laser irradiation. Herein, multivalent polymer-functionalized AuNRs (AuNRs@pDMAEMA-C4) was constructed as a highly stable and biocompatible photothermal agent for enhanced antibacterial therapy. The functionalized polymer was synthetized via the reversible addition-fragmentation chain transfer polymerization and subsequently quaternized. Moreover, positively charged AuNRs@pDMAEMA-C4 can easily capture the bacterial surface via electrostatic interactions. The integration of photothermal therapy of AuNRs and chemotherapy of functionalized polymer can achieve enhanced antibacterial effects. Under 808 nm laser irradiation, AuNRs@pDMAEMA-C4 possessed excellent photothermal conversion capability and can kill gram-positive and gram-negative bacteria. Study of the antibacterial mechanism indicated that the antibacterial action of the prepared photothermal antibacterial agent can cause serious damage of the bacterial outer membranes, result in cytoplasm leakage and bacterial death. The nanocomposites combining with near-infrared laser irradiation can facilitate rapid healing of bacteria-infected wound by rat model of wound infection and histological analysis of the wound tissues. These results suggest that the surface functionalization can be used as potential strategy to fabricate light-activated therapeutic agent for biomedical applications.

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用于增强光热抗菌疗法的稳定且生物兼容的多价聚合物接枝金纳米棒
近红外激光激活的金纳米棒(AuNRs)具有优异的光热特性和可调的表面功能化,被认为是生物医学应用的理想平台。然而,裸露的 AuNRs 对正常细胞具有细胞毒性,并且在激光照射过程中容易聚集。在此,我们构建了多价聚合物功能化 AuNRs(AuNRs@pDMAEMA-C4),作为一种高稳定性和生物相容性的光热剂,用于增强抗菌治疗。这种功能化聚合物是通过可逆加成-断裂链转移聚合法合成的,随后被季铵化。此外,带正电荷的 AuNRs@pDMAEMA-C4 可通过静电相互作用轻松捕获细菌表面。AuNRs 的光热疗法与功能化聚合物的化疗相结合,可以增强抗菌效果。在 808 nm 激光照射下,AuNRs@pDMAEMA-C4 具有优异的光热转换能力,可杀死革兰氏阳性和阴性细菌。抗菌机理研究表明,所制备的光热抗菌剂的抗菌作用可严重破坏细菌外膜,导致细胞质泄漏和细菌死亡。通过大鼠伤口感染模型和伤口组织学分析,纳米复合材料结合近红外激光照射可促进细菌感染伤口的快速愈合。这些结果表明,表面功能化可作为一种潜在的策略,用于制造生物医学应用中的光激活治疗剂。
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来源期刊
Journal of Applied Polymer Science
Journal of Applied Polymer Science 化学-高分子科学
CiteScore
5.70
自引率
10.00%
发文量
1280
审稿时长
2.7 months
期刊介绍: The Journal of Applied Polymer Science is the largest peer-reviewed publication in polymers, #3 by total citations, and features results with real-world impact on membranes, polysaccharides, and much more.
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