Synthetic Strategies of Highly Bioactive Scaffold Bis(indolyl)methane Under Greener Condition- A Comprehensive Review

IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Current topics in medicinal chemistry Pub Date : 2024-08-28 DOI:10.2174/0115680266319238240821080203
Arijit Kundu, Chhanda Mukhopadhyay
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Abstract

Bis(indolyl)Methanes are a major class of heterocycles with considerable promise for technological and biological applications and being fluorescent active as well. Considering the extensive quantity of work on various synthetic techniques, the objective of this study is to measure the previous and current status of research studies related to different types of Bis(indolyl)methane (BIM) derivatives. Currently, research is focused on developing green synthetic strategies for dependable, sustainable and environmentally friendly synthetic processes. The present literature describes the formation of BIM moieties starting from suitable precursors using conventional reaction procedures, as well as reactions mediated by microwaves, ultrasounds, organocatalysts, transition metal catalysts, metal-free ionic liquid catalysts, and other environmentally friendly reaction protocols. The current review discusses the explosive development of different environmentally friendly synthesis routes for bis(indolyl)methane and its analogues during the past few decades. Moreover, this study includes the biological activities such as antibacterial, anticancer, anti-inflammatory, etc., of BIM derivatives, which have been investigated in recent years.
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绿色条件下高生物活性支架双(吲哚基)甲烷的合成策略--综述
双(吲哚基)甲烷是一类主要的杂环化合物,在技术和生物应用方面前景广阔,同时还具有荧光活性。考虑到有关各种合成技术的大量工作,本研究的目的是衡量与不同类型的双(吲哚基)甲烷(BIM)衍生物有关的研究的过去和现状。目前,研究的重点是开发绿色合成策略,以实现可靠、可持续和环保的合成工艺。目前的文献介绍了使用传统反应程序从合适的前体开始形成 BIM 分子的情况,以及由微波、超声波、有机催化剂、过渡金属催化剂、无金属离子液体催化剂和其他环境友好型反应方案介导的反应。本综述讨论了过去几十年中双(吲哚基)甲烷及其类似物不同环境友好型合成路线的爆炸性发展。此外,本研究还包括近年来研究的双(吲哚基)甲烷衍生物的生物活性,如抗菌、抗癌、抗炎等。
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来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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