Synthesis, characterization and biological activity studies of Pd(II) and Pt(II)–2H-benzo[e][1,3]oxazine-2,4(3H)-dione (HBzoxe) complexes

IF 2.2 4区化学 Q2 Engineering Chemical Papers Pub Date : 2024-08-17 DOI:10.1007/s11696-024-03650-9

Wesam H. Khalaf, Subhi A. Al-Jibori, Muhammad Ashfaq, Ahmed S. Faihan, Muhammad Nawaz Tahir, Ahmed S. M. Al-Janabi

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Abstract

Mixed-ligand complexes of Pd(II) and Pt(II) with 2H-benzo[e][1,3] oxazine-2,4(3H)-dione (HBzoxe), tertiary phosphines (dppe, dppp, dppf and Ph₃P), 2,2′-bipyridine (Bipy) and 1,10-phenanthroline (Phen) have been synthesized and characterized by molar conductance measurements, elemental analysis, IR and NMR (¹H, ¹³C and ³¹P) spectroscopy. In addition, the antimicrobial activity assay studies. The results showed that the HBzoxe ligand behaves as a bidentate chelation ligand through the O and N atoms in [M(Bzoxe)₂] {M^II = Pd(1) and Pt(2)} complexes, whereas it acts as monodentate ligand through the oxygen atom in complexes (3–14) to afford a square planner geometry around Pd(II) and Pt(II) for all of the complexes. All of the complexes were moderately active on all the bacteria tested (Staphylococcus aureus and Escherichia coli). Hirshfeld surface analysis was carried out to investigate the cooperative non-covalent supramolecular interactions within the various complexes.

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钯（II）和铂（II）-2H-苯并[e][1,3]恶嗪-2,4(3H)-二酮（HBzoxe）配合物的合成、表征和生物活性研究

钯（II）和铂（II）与 2H-苯并[e][1,3]恶嗪-2,4(3H)-二酮（HBzoxe）、叔膦（dppe、dppp、dppf 和 Ph3P）、2,2′-联吡啶（Bipy）和 1.10-菲罗啉（Phen）的混合配体配合物已经合成，并通过摩尔电导测量、元素分析、红外光谱和核磁共振（1H、13C 和 31P 光谱）进行了表征、通过摩尔电导测量、元素分析、红外光谱和核磁共振（1H、13C 和 31P）光谱，对这些化合物进行了合成和表征。此外，还进行了抗菌活性测定研究。结果表明，在 [M(Bzoxe)2] {MII = Pd(1) 和 Pt(2)} 复合物中，HBzoxe 配体通过 O 原子和 N 原子作为双齿螯合配体，而在复合物（3-14）中，它通过氧原子作为单齿配体，使所有复合物在 Pd(II) 和 Pt(II) 周围形成方形平面几何。所有配合物对所有测试细菌（金黄色葡萄球菌和大肠杆菌）都具有中等活性。为了研究各种复合物内部的合作性非共价超分子相互作用，我们进行了 Hirshfeld 表面分析。

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来源期刊

Chemical Papers Chemical Engineering-General Chemical Engineering

CiteScore

3.30

自引率

4.50%

发文量

590

期刊介绍： Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.