Evaluation of antihypertensive drug-induced changes in mandibular bone using fractal analysis

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-01-01 DOI:10.1016/j.oooo.2024.08.015

Firdevs Aşantoğrol MDS, DDS , Ayşe Nur Koruyucu MDS, DDS

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Abstract

Objective

The aim was to evaluate changes in trabecular and cortical mandibular bone caused by antihypertensive (AHT) drugs through fractal analysis.

Study Design

This retrospective study included 230 patients who were taking AHT medication and had no conditions affecting bone metabolism other than hypertension. A control group of 230 healthy, sex-matched individuals was also included. Patients were divided into subgroups according to AHT drugs: thiazide diuretics (TDs), beta-blockers (BBs), angiotensin converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs), and a combination of drugs. The fractal dimension (FD) was calculated bilaterally in 5 regions of interest (ROI 1 – ROI 5) including 4 trabecular regions and 1 cortical region using Image J software.

Results

Mean FD values were significantly higher in all ROIs for the study group compared to the control group (P < .001). FDs were significantlty higher for BB, ACEI, ARB, CCB, and combined subgroups compared to controls in ROIs 1, 2, and 4; for ACEI and CCB subgroups compared to controls in ROI 3; and for TD, BB, ACEI, ARB, CCB, and combined subgroups compared to controls in ROI 5 (P < .001).

Conclusions

AHTs may increase FD values of the trabecular and cortical structures. Assessment of the effects of AHT drugs is essential for predicting the prognosis for bone healing after tooth extraction, osseointegration after implant surgery, or other surgical procedures.

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利用分形分析评估降压药引起的下颌骨变化

目的是通过分形分析评估抗高血压（AHT）药物对下颌骨骨小梁和皮质造成的变化。这项回顾性研究包括 230 名正在服用 AHT 药物的患者，他们除高血压外没有其他影响骨代谢的疾病。研究还包括一个由 230 名性别匹配的健康人组成的对照组。根据 AHT 药物将患者分为不同的亚组：噻嗪类利尿剂 (TD)、β-受体阻滞剂 (BB)、血管紧张素转换酶抑制剂 (ACEI)、血管紧张素受体阻滞剂 (ARB)、钙通道阻滞剂 (CCB) 以及药物组合。使用 Image J 软件计算了双侧 5 个感兴趣区（ROI 1 - ROI 5）的分形维数（FD），包括 4 个小梁区域和 1 个皮质区域。与对照组相比，研究组所有 ROI 的平均 FD 值都明显高于对照组 ( < .001)。在 ROI 1、2 和 4 中，BB、ACEI、ARB、CCB 和联合亚组的 FD 值明显高于对照组；在 ROI 3 中，ACEI 和 CCB 亚组的 FD 值明显高于对照组；在 ROI 5 中，TD、BB、ACEI、ARB、CCB 和联合亚组的 FD 值明显高于对照组 ( < .001)。AHTs 可增加小梁和皮质结构的 FD 值。评估 AHT 药物的作用对于预测拔牙后骨愈合、种植手术后骨结合或其他外科手术的预后至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.