V. R. Akhmetova, D. V. Leont’ev, N. S. Akhmadiev, E. A. Paramonov
{"title":"Catalytic thiomethylation of indoles","authors":"V. R. Akhmetova, D. V. Leont’ev, N. S. Akhmadiev, E. A. Paramonov","doi":"10.1007/s11172-024-4315-6","DOIUrl":null,"url":null,"abstract":"<div><p>The catalysis of direct thiomethylation of 1<i>H</i>-indole and tryptophan under the action of the formaldehyde—mercaptan reagent system in the presence of acids and bases, phosphorus oxide and the oxidative system I<sub>2</sub>/NaOH was studied. A mechanism for the catalysis of the multicomponent thiomethylation reaction was proposed based on the results of mass spectrometric study of intermediate compounds.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"73 7","pages":"1962 - 1967"},"PeriodicalIF":1.7000,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Chemical Bulletin","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11172-024-4315-6","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The catalysis of direct thiomethylation of 1H-indole and tryptophan under the action of the formaldehyde—mercaptan reagent system in the presence of acids and bases, phosphorus oxide and the oxidative system I2/NaOH was studied. A mechanism for the catalysis of the multicomponent thiomethylation reaction was proposed based on the results of mass spectrometric study of intermediate compounds.
期刊介绍：
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.
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