Tetranitrosyl iron complexes with 4-chloro- and 4-methoxybenzenemethanethiolyls as new nitrogen monoxide donors: synthesis, structure, and biological activity

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Russian Chemical Bulletin Pub Date : 2024-08-31 DOI:10.1007/s11172-024-4327-2

N. A. Sanina, A. S. Konyukhova, D. V. Korchagin, G. V. Shilov, V. O. Novikova, L. M. Mazina, O. V. Pokidova, N. S. Emelyanova, T. S. Stupina, A. V. Kulikov, M. A. Blagov, S. M. Aldoshin

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Abstract

Two new binuclear tetranitrosyl iron complexes of the composition [Fe₂L₂(NO)₄] (1, L = 4-methoxybenzenemethanethiolyl; 2, L = 4-chlorobenzenemethanethiolyl) were synthesized. Their crystals were characterized by X-ray diffraction, by IR, ESR, UV, and Mössbauer spectroscopies, and by elemental analysis. The NO-donating properties and transformations of the complexes in physiological solutions, including reactions in the presence of bovine serum albumin, were studied. The cytotoxicity of compounds 1 and 2 was studied on normal Vero cells. The effect of the complexes on enzymes was investigated taking guanylate cyclase and adenylate cyclase as examples. The results obtained allow one to recommend compound 2 for further investigations as a potential drug with vaso- and bronchodilator properties.

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以 4-氯和 4-甲氧基苯甲硫酚作为新的一氧化氮供体的四亚硝基铁络合物：合成、结构和生物活性

合成了两种新的双核四硝基铁配合物，其组成为 [Fe2L2(NO)4] （1，L = 4-甲氧基苯甲硫酚；2，L = 4-氯苯甲硫酚）。通过 X 射线衍射、红外光谱、电子能谱、紫外光谱、莫斯鲍尔光谱和元素分析对它们的晶体进行了表征。研究了这些复合物在生理溶液中的氮氧化物捐献特性和转化，包括在牛血清白蛋白存在下的反应。研究了化合物 1 和 2 对正常 Vero 细胞的细胞毒性。以鸟苷酸环化酶和腺苷酸环化酶为例，研究了复合物对酶的影响。根据研究结果，我们建议将化合物 2 作为一种具有血管和支气管扩张特性的潜在药物进行进一步研究。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.