Pulmonary alveolar proteinosis complicated by lung cancer with favorable prognosis: a case report and literature review

IF 3.5 3区 医学 Q2 ONCOLOGY Frontiers in Oncology Pub Date : 2024-09-12 DOI:10.3389/fonc.2024.1434631
Ying Wu, Wenhui Guan, Jiaxi Deng, Wenwei Mo, Beini Xu, Jiahao Zhang, Huixin Jiang, Jie Liu, Xinqing Lin, Chengzhi Zhou
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Abstract

With the increasing incidence of lung cancer, the coexistence of pulmonary alveolar proteinosis (PAP) and lung cancer is becoming more common. However, the standard treatment protocols for patients with both conditions are still being explored. The conflict between the rapidly evolving therapeutic approaches for tumors and the limited treatment options for PAP presents a significant challenge for clinicians. Determining the optimal timing of treatment for both conditions to maximize patient benefit is a clinical conundrum. Here, we report a rare case of PAP complicated by lung adenocarcinoma, where interstitial lung changes worsened after neoadjuvant therapy but improved significantly following surgical resection of the lung adenocarcinoma. This case highlights the importance of prioritizing tumor treatment in patients with lung cancer complicated by PAP and examines the interplay between the two conditions, as well as potential therapeutic strategies.
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预后良好的肺癌并发肺泡蛋白沉积症:病例报告和文献综述
随着肺癌发病率的上升,肺泡蛋白沉积症(PAP)和肺癌并存的情况越来越常见。然而,针对这两种疾病患者的标准治疗方案仍在探索之中。肿瘤治疗方法的快速发展与肺泡蛋白沉积症治疗方案的有限性之间的矛盾给临床医生带来了巨大挑战。如何确定这两种疾病的最佳治疗时机,使患者获益最大化是一个临床难题。在此,我们报告了一例罕见的肺腺癌并发 PAP 病例,患者在接受新辅助治疗后肺间质病变恶化,但在手术切除肺腺癌后病情明显好转。该病例强调了对并发 PAP 的肺癌患者优先进行肿瘤治疗的重要性,并探讨了这两种疾病之间的相互作用以及潜在的治疗策略。
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来源期刊
Frontiers in Oncology
Frontiers in Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
6.20
自引率
10.60%
发文量
6641
审稿时长
14 weeks
期刊介绍: Cancer Imaging and Diagnosis is dedicated to the publication of results from clinical and research studies applied to cancer diagnosis and treatment. The section aims to publish studies from the entire field of cancer imaging: results from routine use of clinical imaging in both radiology and nuclear medicine, results from clinical trials, experimental molecular imaging in humans and small animals, research on new contrast agents in CT, MRI, ultrasound, publication of new technical applications and processing algorithms to improve the standardization of quantitative imaging and image guided interventions for the diagnosis and treatment of cancer.
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