Effectiveness of Original Monovalent and Bivalent COVID-19 Vaccines Against COVID-19-associated Emergency Department and Urgent Care Encounters in Immunocompetent Pregnant Persons, VISION Network, June 2022–August 2023

IF 3.8 4区医学 Q2 IMMUNOLOGY Open Forum Infectious Diseases Pub Date : 2024-08-28 DOI:10.1093/ofid/ofae481

Allison Avrich Ciesla, Victoria Lazariu, Kristin Dascomb, Stephanie A Irving, Brian E Dixon, Manjusha Gaglani, Allison L Naleway, Shaun J Grannis, Sarah Ball, Anupam B Kharbanda, Gabriela Vazquez-Benitez, Nicola P Klein, Karthik Natarajan, Toan C Ong, Peter J Embi, Katherine E Fleming-Dutra, Ruth Link-Gelles, Ousseny Zerbo

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Abstract

Pregnant people face increased risk of severe COVID-19. Current guidelines recommend Updated (2023-2024) COVID-19 vaccination for those aged ≥6 months, irrespective of pregnancy status. To refine recommendations for pregnant people, further data is needed. Using a test-negative design, we evaluated COVID-19 vaccine effectiveness (VE) against medically-attended COVID-19 with COVID-19–like illness among pregnant people aged 18-45 years during June 2022–August 2023. VE of doses received during pregnancy was 52% (95%CI: 29-67%), <6 months prior to pregnancy was 28% (95%CI: 11-42%), and ≥6 months prior to pregnancy was 6% (95%CI: -11-21%). Pregnant people should stay up to date with recommended COVID-19 vaccination.

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原始单价和二价 COVID-19 疫苗对免疫功能正常的孕妇接种 COVID-19 相关急诊科和急诊护理的有效性，VISION 网络，2022 年 6 月至 2023 年 8 月

孕妇罹患严重 COVID-19 的风险增加。目前的指导方针建议年龄≥6 个月的人群接种最新（2023-2024 年）COVID-19 疫苗，无论是否怀孕。要完善针对孕妇的建议，还需要进一步的数据。我们采用阴性试验设计，评估了2022年6月至2023年8月期间18-45岁孕妇接种COVID-19疫苗预防COVID-19类疾病的有效性（VE）。怀孕期间接种疫苗的有效率为52%（95%CI：29-67%），怀孕前6个月接种疫苗的有效率为28%（95%CI：11-42%），怀孕前≥6个月接种疫苗的有效率为6%（95%CI：-11-21%）。孕妇应及时接种推荐的 COVID-19 疫苗。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.