Therapeutic Drug Monitoring of Long Acting Rilpivirine and Cabotegravir for Treatment of HIV-1 Infection – A Case Series of Five Patients with One Virologic Failure after Development of Two-Class Resistance
Jacob Gerstenberg, Hartwig Klinker, Michael Baier, Amrei von Braun, Ulrich Seybold, Carlotta Helbig, Martin Däumer, Klaus Korn, Christoph Stephan, Benjamin T Schleenvoigt
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Abstract
Virologic failure of long-acting rilpivirine/cabotegravir is rare but may result in severely limited treatment options. Known risk factors cannot predict all cases. Therapeutic drug monitoring (TDM) may help identify patients-at-risk, but reliable thresholds are missing. We report retrospective TDM in a cohort of five patients, including one virological failure.
期刊介绍：
Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.
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