Effectiveness of mobile smoking cessation treatment with 1‐week nicotine replacement therapy sampling at outdoor smoking hotspots: A cluster randomized controlled trial

IF 5.2 1区医学 Q1 PSYCHIATRY Addiction Pub Date : 2024-09-11 DOI:10.1111/add.16666

Wan Jia Aaron He, Qi Wang, Ching Han Helen Chan, Tzu Tsun Luk, Man Ping Wang, Siu Chee Sophia Chan, Tai Hing Lam, Yee Tak Derek Cheung

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Abstract

AimsTo evaluate the effectiveness of mobile smoking cessation (SC) treatment with 1‐week nicotine replacement therapy (NRT) sampling on recruitment and quitting outcomes.DesignTwo‐arm cluster RCT (1:1 ratio), single‐blinded, at 244 recruitment sessions in Hong Kong outdoor smoking hotspots from October 2018–December 2019.SettingParticipant were recruited by ambassadors and treated at the mobile SC truck.Participants834 adult (≥18 years, male 81.3%) daily smokers, Chinese‐speaking, non‐NRT users in the past month, consented after nurse‐led intervention in mobile SC truck were randomized to the experimental (n = 482 male 79.5%) and the control group (n = 352, male 83.8%).Intervention and comparatorThe experimental group received a 1‐week free NRT sample, an NRT instruction card, and mobile SC treatment including onsite nurse‐led brief medication advice (about 15 minutes) and referral to SC clinics. The control group received the same mobile SC treatment.MeasurementsPrimary outcome was self‐reported quit attempts at 1‐month follow‐up. Secondary outcomes included SC service use at 1 month, and biochemically validated abstinence (exhaled carbon monoxide < 4 ppm; or saliva cotinine < 10 ng/ml) at 6‐month follow‐up. Additionally, a post‐hoc cost analysis was conducted.FindingsBy intention‐to‐treat, the two groups showed similar prevalence of quit attempts (44·4% versus 43·5%, risk ratio (RR) = 1·04, 95% confidence interval (CI) = 0·79–1·37, P = 0·79). Compared with the control group, the experimental group showed lower SC service use at clinics (32·4% versus 44·9%, RR = 0·72, 95%CI = 0·57–0·91, P = 0·006), but no significant difference in validated abstinence (4·6% versus 2·8%, RR = 1·64, 95%CI = 0·76–3·50, P = 0·21). The experimental recruitment sessions recruited more smokers for onsite medication advice than the control session (mean 6·7 vs 5·0, adjusted incident rate ratio = 1·30, 95%CI = 1·08–1·56, P = 0·005).ConclusionsMobile smoking cessation treatment with 1‐week nicotine replacement therapy sampling did not increase quit attempts or abstinence outcomes among recruited daily smokers in Hong Kong. The intervention increased smokers' uptake of onsite medication advice but reduced subsequent smoking cessation service use at clinics.

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在室外吸烟热点进行为期一周的尼古丁替代疗法采样的移动戒烟治疗效果：分组随机对照试验

目的评价流动戒烟车进行为期1周的尼古丁替代疗法（NRT）抽样治疗对招募和戒烟结果的有效性.设计双臂群组RCT（1:1比例），单盲，于2018年10月至2019年12月在香港室外吸烟热点的244个招募场次进行.设置由大使招募参与者并在流动戒烟车进行治疗.参与者834名成年（≥18岁，男性81.实验组接受为期1周的免费NRT样品、NRT指导卡和流动SC治疗，包括现场护士指导的简短用药建议（约15分钟）和转诊至SC诊所。测量主要结果是随访 1 个月时自我报告的戒烟尝试。次要结果包括 1 个月时 SC 服务的使用情况，以及 6 个月随访时经生化验证的戒烟情况（呼出一氧化碳 < 4 ppm；或唾液中可替宁 < 10 ng/ml）。此外，还进行了事后成本分析。研究结果通过意向治疗，两组的戒烟尝试率相似（44-4% 对 43-5%，风险比 (RR) = 1-04，95% 置信区间 (CI) = 0-79-1-37，P = 0-79）。与对照组相比，实验组在诊所使用 SC 服务的比例较低（32-4% 对 44-9%，RR = 0-72，95%CI = 0-57-0-91，P = 0-006），但在验证戒断率方面没有显著差异（4-6% 对 2-8%，RR = 1-64，95%CI = 0-76-3-50，P = 0-21）。与对照组相比，实验组招募了更多的吸烟者接受现场用药咨询（平均6-7对5-0，调整后的事件发生率比=1-30，95%CI=1-08-1-56，P=0-005）。该干预措施增加了吸烟者对现场药物咨询的接受度，但减少了随后在诊所使用戒烟服务的次数。

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来源期刊

Addiction 医学-精神病学

CiteScore

10.80

自引率

6.70%

发文量

319

审稿时长

3 months

期刊介绍： Addiction publishes peer-reviewed research reports on pharmacological and behavioural addictions, bringing together research conducted within many different disciplines. Its goal is to serve international and interdisciplinary scientific and clinical communication, to strengthen links between science and policy, and to stimulate and enhance the quality of debate. We seek submissions that are not only technically competent but are also original and contain information or ideas of fresh interest to our international readership. We seek to serve low- and middle-income (LAMI) countries as well as more economically developed countries. Addiction’s scope spans human experimental, epidemiological, social science, historical, clinical and policy research relating to addiction, primarily but not exclusively in the areas of psychoactive substance use and/or gambling. In addition to original research, the journal features editorials, commentaries, reviews, letters, and book reviews.