Zinc-based metal–organic frameworks for encapsulation and sustained release of ciprofloxacin for excellent antibacterial activities

IF 2.8 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of chemical technology and biotechnology Pub Date : 2024-08-23 DOI:10.1002/jctb.7736

Abdul Rauf, Mohsin Javed, Muhammad Jahangir, Mehdi Hassan, Anam Tariq, Wajahat Ali, Ali Bahadur, Shahid Iqbal, Sajid Mahmood, Khalid M Alotaibi, Matar Alshalwi

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Abstract

BACKGROUND

In terms of crystalline nanoporous materials, metal–organic frameworks (MOFs) are relatively new. They are self-assembling structures made of organic ligands that serve as linkers between metal centers and metal ions that function as coordination centers. Due to MOFs' high porosity, absence of nonaccessible bulk volume, vast surface areas and variety of pore sizes and topologies, drug delivery via them is becoming more and more common.

RESULTS

Zn-MOF and Zn-MOF@drug were produced using a solvothermal approach in this study and characterized using a variety of methods, including Fourier transform infrared spectroscopy, powder X-ray diffraction and scanning electron microscopy. Utilizing the zone of inhibition and minimum inhibitory concentration approaches, Zn-MOF and Zn-MOF@drug were evaluated for their antibacterial capability against Escherichia coli and Bacillus subtilis, two types of bacteria.

CONCLUSION

The antibacterial potential of Zn-MOF@drug was greater than that of the metal salt, commercially available ZnO, Zn-MOF and ligand alone. The mechanism of antibacterial activity of Zn-MOF@drug was also discussed. © 2024 Society of Chemical Industry (SCI).

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用于包封和持续释放环丙沙星的锌基金属有机框架，具有卓越的抗菌活性

背景在结晶纳米多孔材料方面，金属有机框架（MOFs）相对较新。它们是由有机配体自组装而成的结构，有机配体是金属中心与作为配位中心的金属离子之间的连接体。由于 MOFs 具有高孔隙率、无不可获取的体积、巨大的表面积以及各种孔隙大小和拓扑结构，通过它们进行药物输送正变得越来越普遍。研究结果本研究采用溶热法制备了 Zn-MOF 和 Zn-MOF@药物，并使用傅立叶变换红外光谱、粉末 X 射线衍射和扫描电子显微镜等多种方法对其进行了表征。结论 Zn-MOF@drug 的抗菌潜力大于金属盐、市售 ZnO、Zn-MOF 和单独的配体。此外，还讨论了 Zn-MOF@drug 的抗菌机制。© 2024 化学工业学会（SCI）。

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来源期刊

Journal of chemical technology and biotechnology 工程技术-工程：化工

CiteScore

7.00

自引率

5.90%

发文量

268

审稿时长

1.7 months

期刊介绍： Journal of Chemical Technology and Biotechnology(JCTB) is an international, inter-disciplinary peer-reviewed journal concerned with the application of scientific discoveries and advancements in chemical and biological technology that aim towards economically and environmentally sustainable industrial processes.

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