Regulatory variation at serotonin receptor 1F (HTR1F) modulates arousals and risk for sleep apnea

Satu Strausz, Martin Broberg, Samuel E Jones, Jukka Koskela, Tuomo Kiiskinen, FinnGen, Aarno Palotie, Tuula Palotie, Adel Bachour, Richa Saxena, Samuli Ripatti, Erik Abner, Hanna M. Ollila
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Abstract

Background Sleep apnea is a common sleep disorder affecting at least ten percent of the population. It is caused by lack of breathing during sleep, typically mediated by obstruction of airways or less frequently by misdirected central signals for breathing. The primary risk factor is a high body mass index (BMI), causing airway obstruction. However, understanding risk factors for sleep apnea in non-obese (BMI < 30) individuals requires further exploration.
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血清素受体 1F (HTR1F) 的调节变异可调节唤醒和睡眠呼吸暂停的风险
背景 睡眠呼吸暂停是一种常见的睡眠障碍,至少影响 10% 的人口。睡眠呼吸暂停是由睡眠时呼吸不畅引起的,通常是由于气道阻塞或中枢呼吸信号误导所致。主要风险因素是体重指数(BMI)过高,导致气道阻塞。然而,了解非肥胖(体重指数为 30)人群睡眠呼吸暂停的风险因素还需要进一步探索。
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