Radiochemical separation of 161 Tb from neutron irradiated Gd target by liquid-liquid extraction technique

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-09-02 DOI:10.1515/ract-2024-0286

Ahmed M. Shahr El-Din, Mohamed A. Gizawy, Emad H. Borai

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Abstract

No-carrier-added (NCA) 161 Tb, which has advisable nuclear properties to be applied for cancer radiotherapy was produced at the Egyptian Second Research Reactor (ETRR-2) by neutron irradiation of natural gadolinium target via indirect nuclear reaction. The radiochemical separation of 161 Tb from irradiated gadolinium target was investigated based on solvent extraction technique using Cyanex 302. Several separation parameters were checked and optimized. According to the obtained results, the separation process of the investigated radioisotopes proceeds in two steps. The first step is an extraction of all of them into the organic phase in which the extraction % (98 %) was optimized at pH 4, 0.15 M of Cyanex 302 and 2.5 h extraction time. Moreover, the slope analysis method confirmed the participation of 2 mol of the organic extractant for the separation of 161 Tb from irradiated gadolinium. The second step is the separation of the 161 Tb isotope that was purified by the stripping of 159Gd with a citrate solution at pH 9, which is considered as a highly efficient and promising method for separation and purification of the two radioisotopes.

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利用液液萃取技术从中子辐照钆靶中放射性化学分离 161 Tb

埃及第二研究堆（ETRR-2）通过间接核反应对天然钆靶进行中子辐照，制备出了无载体添加（NCA）的 161 Tb，它具有适用于癌症放射治疗的适当核特性。通过使用 Cyanex 302 溶剂萃取技术，对从辐照钆靶中分离出 161 Tb 的放射化学过程进行了研究。对几个分离参数进行了检查和优化。根据获得的结果，所研究的放射性同位素的分离过程分为两个步骤。第一步是将所有放射性同位素萃取到有机相中，在 pH 值为 4、Cyanex 302 浓度为 0.15 M、萃取时间为 2.5 小时的条件下，萃取率达到最佳（98%）。此外，斜率分析法证实，2 摩尔的有机萃取剂参与了从辐照钆中分离出 161 Tb 的过程。第二步是通过在 pH 值为 9 的柠檬酸盐溶液中剥离 159Gd 来分离纯化 161 Tb 同位素。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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