V. D. Fedotovskaya, S. S. Zamai, M. V. Zotova, A. N. Masyugin, F. V. Zelenov, N. A. Luzan, T. N. Zamai, A. A. Koshmanova, D. A. Kirichenko, E. D. Nikolaeva, O. S. Kolovskaya, I. A. Shchugoreva, G. S. Zamai, V. N. Zabluda, A. A. Borus, A. S. Bukatin, I. N. Lapin, V. A. Svetlichnyi, E. V. Morozov, K. A. Luk’yanenko, F. G. Zograf, F. N. Tomilin, A. E. Sokolov, A. A. Narodov, R. G. Galeev, A. S. Kichkailo
{"title":"Magnetic Nanodiscs That Destroy Glioblastoma Cells in a Targeted Way in an Alternating Nonheating Magnetic Field","authors":"V. D. Fedotovskaya, S. S. Zamai, M. V. Zotova, A. N. Masyugin, F. V. Zelenov, N. A. Luzan, T. N. Zamai, A. A. Koshmanova, D. A. Kirichenko, E. D. Nikolaeva, O. S. Kolovskaya, I. A. Shchugoreva, G. S. Zamai, V. N. Zabluda, A. A. Borus, A. S. Bukatin, I. N. Lapin, V. A. Svetlichnyi, E. V. Morozov, K. A. Luk’yanenko, F. G. Zograf, F. N. Tomilin, A. E. Sokolov, A. A. Narodov, R. G. Galeev, A. S. Kichkailo","doi":"10.1134/s2635167624600834","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The need to develop a surgical instrument that can most effectively and minimally invasively remove a malignant tumor, and distinguish and destroy only tumor cells without damaging the normal cells of healthy tissue surrounding the tumor is being considered. To achieve this goal, it is proposed to use nanodiscs with special magnetic, electronic and optical properties. Nanodiscs modified with recognition ligands (aptamers) are able to bind to tumor cells and destroy them under the influence of a weak, nonheating alternating magnetic field. This allows for effective tumor destruction while minimizing the impact on surrounding healthy tissue.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanotechnologies in Russia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s2635167624600834","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Engineering","Score":null,"Total":0}
引用次数: 0
Abstract
The need to develop a surgical instrument that can most effectively and minimally invasively remove a malignant tumor, and distinguish and destroy only tumor cells without damaging the normal cells of healthy tissue surrounding the tumor is being considered. To achieve this goal, it is proposed to use nanodiscs with special magnetic, electronic and optical properties. Nanodiscs modified with recognition ligands (aptamers) are able to bind to tumor cells and destroy them under the influence of a weak, nonheating alternating magnetic field. This allows for effective tumor destruction while minimizing the impact on surrounding healthy tissue.
期刊介绍：
Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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