Active Avoidance Learning in Rats with Different Audiogenic Epilepsy Proneness

Pub Date : 2024-08-29 DOI:10.1134/s0022093024040239

N. M. Surina, I. B. Fedotova, I. I. Poletaeva

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Abstract

Learning difficulties are a fairly common comorbid complication in patients diagnosed with epilepsy. The relationship between the predisposition to epilepsy and the ability to learn is an important problem. The aim of the study was to analyze how the learning capacity differs in rats with different predispositions to reflex audiogenic epilepsy (AE). The success of active avoidance (AAC) conditioning in the shuttle box in rats of 3 strains was evaluated. These were rats predisposed to audiogenic epilepsy—the Krushinsky–Molodkina strain (KM), strain “4” (selected from a population of F2 hybrids of the KM strain and AE non-prone Wistars) and rats of “0” strain, selected for the absence of AE from the same population (i.e. these strains differ radically in AE-proneness, but have a similar genetic background). The training was conducted continuously for 5 days (20 presentations per day). Experiments have shown significantly more successful acquisition of this skill in rats of the “0” strain: in total, 75% of animals reached the learning criteria for 5 days of AAC training (70% AAC per day). The “4” strain rats indices were intermediate—41.7%, and only 1 from the 12 rats of the KM strain (8.3%) acquired the task according to this protocol. Thus, it was possible to identify more successful learning in rats, selected for the absence of AE seizures (strain “0”) compared to rats of the KM and “4” strains (expressing tonic seizures of maximum intensity in response to sound exposure). The weakest acquisition was revealed in the KM strain, in which the selection process duration for AE proneness was significantly longer than in the rats of the “4” strain.

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不同听源性癫痫易感性大鼠的主动回避学习

摘要学习困难是被诊断为癫痫的患者中相当常见的并发症。癫痫易感性与学习能力之间的关系是一个重要问题。本研究旨在分析具有不同反射性听源性癫痫（AE）倾向的大鼠的学习能力有何差异。研究评估了3个品系的大鼠在穿梭箱中主动回避（AAC）条件反射的成功率。它们分别是易患听源性癫痫的大鼠--Krushinsky-Molodkin品系（KM）、"4 "品系（选自KM品系和无听源性癫痫的Wistars大鼠的F2杂交种群）和 "0 "品系（选自同一种群中无听源性癫痫的大鼠）（即这三个品系在听源性癫痫易感性方面存在根本性差异，但具有相似的遗传背景）。训练连续进行了 5 天（每天 20 次）。实验表明，"0 "品系大鼠对这一技能的习得成功率明显更高：5 天的 AAC 训练（每天 70% 的 AAC）共有 75% 的动物达到了学习标准。4 "品系大鼠的指数为中等-41.7%，而 12 只 KM 品系大鼠中只有 1 只（8.3%）按照该方案学会了这项任务。因此，与 KM 和 "4 "品系（对声音暴露表现出最大强度的强直性发作）的大鼠相比，因没有 AE 发作而被选中的大鼠（"0 "品系）的学习成功率更高。KM品系大鼠的习得能力最弱，其AE敏感性的选择过程持续时间明显长于 "4 "品系大鼠。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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