Distribution of mechanical properties of native human ligamentum flavum depending on histopathological changes.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Biomedical Physics & Engineering Express Pub Date : 2024-09-10 DOI:10.1088/2057-1976/ad78e2
Filip Samal,Vojtech Cerny,Petr Kujal,Jakub Jezek,Jiri Skala-Rosenbaum,Josef Sepitka
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Abstract

This study aimed to characterize the mechanical properties of native human ligamentum flavum (LF) and correlate them with histopathological changes. Mechanical property gradients across the cranial, medial, and caudal regions of LF were mapped and compared with histological sections. We also compared lumbar spinal stenosis (LSS) samples with disc herniation (DH) samples as reference material to identify differences in mechanical properties and histopathological features. Our results revealed significant heterogeneity in LF mechanical properties, with local variations correlating with specific histopathological changes such as chondroid metaplasia and loss of elastic fibers. These findings underscore the importance of considering LF heterogeneity in mechanical characterization and provide insights into its behavior under pathological conditions.
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人体原生黄韧带机械性能的分布取决于组织病理学变化。
本研究旨在描述原生人体黄韧带(LF)的机械特性,并将其与组织病理学变化联系起来。我们绘制了黄韧带头端、内侧和尾端区域的机械特性梯度图,并将其与组织病理学切片进行了比较。我们还将腰椎管狭窄症(LSS)样本与作为参考材料的椎间盘突出症(DH)样本进行了比较,以确定机械性能和组织病理学特征的差异。我们的研究结果表明,腰椎间盘突出症样本的机械性能存在明显的异质性,局部变化与软骨化生和弹性纤维缺失等特定的组织病理学变化相关。这些发现强调了在机械特性分析中考虑 LF 异质性的重要性,并为了解其在病理条件下的行为提供了见解。
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来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
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