Whole-Genome Sequencing Identifies Functional Genes for Environmental Adaptation in Chinese Sheep.

IF 6.6 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Genetics and Genomics Pub Date : 2024-09-09 DOI:10.1016/j.jgg.2024.08.011
Yinan Niu,Yefang Li,Yuhetian Zhao,Xiaohong He,Qianjun Zhao,Yabin Pu,Yuehui Ma,Lin Jiang
{"title":"Whole-Genome Sequencing Identifies Functional Genes for Environmental Adaptation in Chinese Sheep.","authors":"Yinan Niu,Yefang Li,Yuhetian Zhao,Xiaohong He,Qianjun Zhao,Yabin Pu,Yuehui Ma,Lin Jiang","doi":"10.1016/j.jgg.2024.08.011","DOIUrl":null,"url":null,"abstract":"Sheep (Ovis aries), among the first domesticated species, are now globally widespread and exhibit remarkable adaptability to diverse environments. In this study, we perform whole-genome sequencing of 266 animals from 18 distinct Chinese sheep populations, each displaying unique phenotypes indicative of adaptation to varying environmental conditions. Integrating 131 environmental factors with single nucleotide polymorphism variations, we conduct a comprehensive genetic-environmental association analysis. This analysis identifies 35 key genes likely integral to the environmental adaptation of sheep. The functions of these genes include fat tail formation (HOXA10, HOXA11, JAZF1), wool characteristics (FER, FGF5, MITF, PDE4B), horn phenotypes (RXFP2), reproduction (HIBADH, TRIM71, C6H4orf22) and growth traits (ADGRL3, TRHDE). Notably, we observe a significant correlation between the frequency of missense mutations in the PAPSS2 and RXFP2 genes and variations in altitude. Our study reveals candidate genes for adaptive variation in sheep and demonstrates the diversity in the ways sheep adapt to their environment.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":"47 1","pages":""},"PeriodicalIF":6.6000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Genetics and Genomics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.jgg.2024.08.011","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Sheep (Ovis aries), among the first domesticated species, are now globally widespread and exhibit remarkable adaptability to diverse environments. In this study, we perform whole-genome sequencing of 266 animals from 18 distinct Chinese sheep populations, each displaying unique phenotypes indicative of adaptation to varying environmental conditions. Integrating 131 environmental factors with single nucleotide polymorphism variations, we conduct a comprehensive genetic-environmental association analysis. This analysis identifies 35 key genes likely integral to the environmental adaptation of sheep. The functions of these genes include fat tail formation (HOXA10, HOXA11, JAZF1), wool characteristics (FER, FGF5, MITF, PDE4B), horn phenotypes (RXFP2), reproduction (HIBADH, TRIM71, C6H4orf22) and growth traits (ADGRL3, TRHDE). Notably, we observe a significant correlation between the frequency of missense mutations in the PAPSS2 and RXFP2 genes and variations in altitude. Our study reveals candidate genes for adaptive variation in sheep and demonstrates the diversity in the ways sheep adapt to their environment.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
全基因组测序发现中国绵羊适应环境的功能基因
绵羊(Ovis aries)是最早被驯化的物种之一,现已遍布全球,并表现出对不同环境的卓越适应能力。在这项研究中,我们对来自 18 个不同中国绵羊种群的 266 只绵羊进行了全基因组测序。将 131 种环境因素与单核苷酸多态性变异相结合,我们进行了全面的遗传环境关联分析。该分析确定了 35 个可能与绵羊的环境适应性密不可分的关键基因。这些基因的功能包括肥尾形成(HOXA10、HOXA11、JAZF1)、羊毛特征(FER、FGF5、MITF、PDE4B)、羊角表型(RXFP2)、繁殖(HIBADH、TRIM71、C6H4orf22)和生长性状(ADGRL3、TRHDE)。值得注意的是,我们观察到 PAPSS2 和 RXFP2 基因的错义突变频率与海拔变化之间存在显著的相关性。我们的研究揭示了绵羊适应性变异的候选基因,并展示了绵羊适应环境方式的多样性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Genetics and Genomics
Journal of Genetics and Genomics 生物-生化与分子生物学
CiteScore
8.20
自引率
3.40%
发文量
4756
审稿时长
14 days
期刊介绍: The Journal of Genetics and Genomics (JGG, formerly known as Acta Genetica Sinica ) is an international journal publishing peer-reviewed articles of novel and significant discoveries in the fields of genetics and genomics. Topics of particular interest include but are not limited to molecular genetics, developmental genetics, cytogenetics, epigenetics, medical genetics, population and evolutionary genetics, genomics and functional genomics as well as bioinformatics and computational biology.
期刊最新文献
Deciphering the influence of gut and oral microbiomes on menopause for healthy aging. KanCell: dissecting cellular heterogeneity in biological tissues through integrated single-cell and spatial transcriptomics. Genomic insights into the genetic diversity, lateral gaits and high-altitude adaptation of Chakouyi (CKY) horses. Integrated analysis and systematic characterization of the regulatory network for human germline development. Znf706 regulates germ plasm assembly and primordial germ cell development in zebrafish.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1