Exploring the potential of epigenetic clocks in aging research

IF 4.2 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS Methods Pub Date : 2024-09-07 DOI:10.1016/j.ymeth.2024.09.001

Yuduo Hao , Kaiyuan Han , Ting Wang , Junwen Yu , Hui Ding , Fuying Dao

引用次数: 0

Abstract

The process of aging is a notable risk factor for numerous age-related illnesses. Hence, a reliable technique for evaluating biological age or the pace of aging is crucial for understanding the aging process and its influence on the progression of disease. Epigenetic alterations are recognized as a prominent biomarker of aging, and epigenetic clocks formulated on this basis have been shown to provide precise estimations of chronological age. Extensive research has validated the effectiveness of epigenetic clocks in determining aging rates, identifying risk factors for aging, evaluating the impact of anti-aging interventions, and predicting the emergence of age-related diseases. This review provides a detailed overview of the theoretical principles underlying the development of epigenetic clocks and their utility in aging research. Furthermore, it explores the existing obstacles and possibilities linked to epigenetic clocks and proposes potential avenues for future studies in this field.

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探索表观遗传时钟在衰老研究中的潜力。

衰老过程是许多老年相关疾病的一个显著风险因素。因此，评估生物年龄或衰老速度的可靠技术对于了解衰老过程及其对疾病进展的影响至关重要。表观遗传学改变被认为是衰老的一个重要生物标志物，在此基础上制定的表观遗传学时钟已被证明可以精确地估算计时年龄。广泛的研究已经验证了表观遗传时钟在确定衰老率、识别衰老风险因素、评估抗衰老干预措施的影响以及预测老年相关疾病的出现方面的有效性。本综述详细概述了表观遗传时钟发展的理论基础及其在衰老研究中的应用。此外，它还探讨了与表观遗传时钟相关的现有障碍和可能性，并提出了该领域未来研究的潜在途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Methods 生物-生化研究方法

CiteScore

9.80

自引率

2.10%

发文量

222

审稿时长

11.3 weeks

期刊介绍： Methods focuses on rapidly developing techniques in the experimental biological and medical sciences. Each topical issue, organized by a guest editor who is an expert in the area covered, consists solely of invited quality articles by specialist authors, many of them reviews. Issues are devoted to specific technical approaches with emphasis on clear detailed descriptions of protocols that allow them to be reproduced easily. The background information provided enables researchers to understand the principles underlying the methods; other helpful sections include comparisons of alternative methods giving the advantages and disadvantages of particular methods, guidance on avoiding potential pitfalls, and suggestions for troubleshooting.