RNA Modifications Shape Hematopoietic Stem Cell Aging: Beyond the Code

IF 3 4区 生物学 Q1 Biochemistry, Genetics and Molecular Biology FEBS Letters Pub Date : 2024-09-09 DOI:10.1002/1873-3468.15014
Inge van der Werf, Jenna Sneifer, Catriona Jamieson
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RNA 修饰影响造血干细胞衰老:超越代码
造血系统衰老的特点是造血干细胞(HSC)和生态位退化,导致髓系定向分化、B细胞和T细胞淋巴生成减少、HSC动员增加以及骨髓中脂肪沉积。在造血干细胞衰老过程中,RNA剪接和编辑的改变都会导致髓系倾斜和炎症反应性转录因子增加,这突出了表转录组机制在获得与年龄相关表型中的重要性。
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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
7.00
自引率
2.90%
发文量
303
审稿时长
1.0 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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