Fabrication of MIL-101(Fe)-embedded biopolymeric films and their biomedical applications

IF 2.8 4区 工程技术 Q2 POLYMER SCIENCE Macromolecular Research Pub Date : 2024-09-03 DOI:10.1007/s13233-024-00305-2
Banu Kocaaga, Gamze Bagimsiz, Ibrahim Avni Alev, Mehran Aliari Miavaghi, Ahmet Sirkecioglu, Saime Batirel, Fatma Seniha Guner
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Abstract

The development of wound-dressing materials with superior therapeutic effects, controlled bioactive agent release, and optimal mechanical properties is crucial in healthcare. This study introduces innovative hydrogel films designed for the sustained release of the local anesthetic drug Procaine (PC), triggered by pH changes. These films are composed of MIL-101(Fe) particles and pectin polymers. MIL-101(Fe) was chosen for its high surface area, stability in aqueous environments, and biocompatibility, ensuring low toxicity to normal cells. MIL-101(Fe)-embedded-pectin hydrogels were synthesized and characterized using Fourier-transformed infrared (FTIR) spectroscopy, thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), X-ray diffraction (XRD), inductively coupled plasma (ICP) spectrometry, particle size analysis, and goniometry. Rheological analysis assessed the hydrogels’ viscoelastic behavior, and UV-spectrophotometry was utilized for drug loading and release studies. The hydrogels exhibited shear-thinning properties, enhancing shape adaptability and recovery, crucial for wound-dressing applications. Controlled drug release was achieved by maintaining the PC solution’s pH between 8.2 and 9.8 during the drug-loading step. The hydrogel film’s impact on wound healing was evaluated through an in vitro wound healing assay, and cytotoxicity was assessed using a WST-1 cell proliferation assay with human dermal fibroblast cells. Results demonstrated that pectin composites enhance cell viability and support fibroblast cell migration without adverse effects, indicating their potential for effective wound healing applications. This study highlights the potential of MIL-101(Fe)-embedded-pectin hydrogels in advancing wound care technology.

Graphical Abstract

MIL-101(Fe)-embedded pectin film as wound dressing

Abstract Image

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嵌入 MIL-101(Fe)的生物聚合物薄膜的制作及其生物医学应用
开发具有卓越治疗效果、可控生物活性剂释放和最佳机械性能的伤口敷料在医疗保健领域至关重要。本研究介绍了专为局部麻醉药物普鲁卡因(PC)的持续释放而设计的创新型水凝胶薄膜,该药物由 pH 值变化触发。这些薄膜由 MIL-101(Fe) 颗粒和果胶聚合物组成。之所以选择 MIL-101(Fe),是因为它具有高比表面积、在水环境中的稳定性和生物相容性,可确保对正常细胞的低毒性。使用傅立叶变换红外光谱(FTIR)、热重分析(TGA)、扫描电子显微镜(SEM)、X 射线衍射(XRD)、电感耦合等离子体(ICP)光谱仪、粒度分析和测角仪合成并表征了 MIL-101(Fe)-嵌入pectin 水凝胶。流变学分析评估了水凝胶的粘弹性行为,紫外分光光度法用于药物负载和释放研究。水凝胶表现出剪切稀化特性,提高了形状适应性和恢复能力,这对伤口包扎应用至关重要。在药物负载步骤中,通过将 PC 溶液的 pH 值保持在 8.2 至 9.8 之间,实现了药物的可控释放。通过体外伤口愈合试验评估了水凝胶膜对伤口愈合的影响,并使用人真皮成纤维细胞的 WST-1 细胞增殖试验评估了细胞毒性。结果表明,果胶复合材料可提高细胞活力,支持成纤维细胞迁移,且无不良影响,表明其具有有效的伤口愈合应用潜力。这项研究凸显了 MIL-101(Fe)-嵌入果胶水凝胶在促进伤口护理技术发展方面的潜力。 图文摘要 MIL-101(Fe)-嵌入果胶薄膜用作伤口敷料
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来源期刊
Macromolecular Research
Macromolecular Research 工程技术-高分子科学
CiteScore
4.70
自引率
8.30%
发文量
100
审稿时长
1.3 months
期刊介绍: Original research on all aspects of polymer science, engineering and technology, including nanotechnology Presents original research articles on all aspects of polymer science, engineering and technology Coverage extends to such topics as nanotechnology, biotechnology and information technology The English-language journal of the Polymer Society of Korea Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.
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