{"title":"Analysis of the Influence of Dose-Dependent Effects of Irradiation with Heavy Particles 12C, 28Si, and 56Fe on Neurogenesis in Adult C57BL/6J Mice","authors":"A. A. Glebov, E. A. Kolesnikova, A. N. Bugay","doi":"10.1134/s1063779624700333","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Modeling the deficiency of mature neurons allows one to predict the development of hippocampus-dependent cognitive impairment in response to irradiation with heavy particles. We use a mathematical model of adult neurogenesis that we developed to calculate the effect of heavy particles on the numbers of mature neurons. To reproduce an experimental data, the model was modified to consider the death of neural stem cells in response to irradiation. As a result, the survival rate of dividing progenitor cells, immature neurons and, for the first time, mature neurons after irradiation with <sup>12</sup>C, <sup>28</sup>Si, and <sup>56</sup>Fe particles was calculated.</p>","PeriodicalId":729,"journal":{"name":"Physics of Particles and Nuclei","volume":"8 1","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics of Particles and Nuclei","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1134/s1063779624700333","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, PARTICLES & FIELDS","Score":null,"Total":0}
引用次数: 0
Abstract
Modeling the deficiency of mature neurons allows one to predict the development of hippocampus-dependent cognitive impairment in response to irradiation with heavy particles. We use a mathematical model of adult neurogenesis that we developed to calculate the effect of heavy particles on the numbers of mature neurons. To reproduce an experimental data, the model was modified to consider the death of neural stem cells in response to irradiation. As a result, the survival rate of dividing progenitor cells, immature neurons and, for the first time, mature neurons after irradiation with 12C, 28Si, and 56Fe particles was calculated.
期刊介绍：
The journal Fizika Elementarnykh Chastits i Atomnogo Yadr of the Joint Institute for Nuclear Research (JINR, Dubna) was founded by Academician N.N. Bogolyubov in August 1969. The Editors-in-chief of the journal were Academician N.N. Bogolyubov (1970–1992) and Academician A.M. Baldin (1992–2001). Its English translation, Physics of Particles and Nuclei, appears simultaneously with the original Russian-language edition. Published by leading physicists from the JINR member states, as well as by scientists from other countries, review articles in this journal examine problems of elementary particle physics, nuclear physics, condensed matter physics, experimental data processing, accelerators and related instrumentation ecology and radiology.
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