Beyond modular enhancers: new questions in cis-regulatory evolution

IF 16.7 1区 生物学 Q1 ECOLOGY Trends in ecology & evolution Pub Date : 2024-09-11 DOI:10.1016/j.tree.2024.07.005
Jeanne M.C. McDonald, Robert D. Reed
{"title":"Beyond modular enhancers: new questions in cis-regulatory evolution","authors":"Jeanne M.C. McDonald, Robert D. Reed","doi":"10.1016/j.tree.2024.07.005","DOIUrl":null,"url":null,"abstract":"<p>Our understanding of how <em>cis</em>-regulatory elements work has advanced rapidly, outpacing our evolutionary models. In this review, we consider the implications of new mechanistic findings for evolutionary developmental biology. We focus on three different debates: whether evolutionary innovation occurs more often via the modification of old <em>cis</em>-regulatory elements or the emergence of new ones; the extent to which individual elements are specific and autonomous or multifunctional and interdependent; and how the robustness of <em>cis</em>-regulatory architectures influences the rate of trait evolution. These discussions lead us to propose new questions for the evo-devo of <em>cis</em>-regulation.</p>","PeriodicalId":23274,"journal":{"name":"Trends in ecology & evolution","volume":null,"pages":null},"PeriodicalIF":16.7000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in ecology & evolution","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.tree.2024.07.005","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ECOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Our understanding of how cis-regulatory elements work has advanced rapidly, outpacing our evolutionary models. In this review, we consider the implications of new mechanistic findings for evolutionary developmental biology. We focus on three different debates: whether evolutionary innovation occurs more often via the modification of old cis-regulatory elements or the emergence of new ones; the extent to which individual elements are specific and autonomous or multifunctional and interdependent; and how the robustness of cis-regulatory architectures influences the rate of trait evolution. These discussions lead us to propose new questions for the evo-devo of cis-regulation.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
超越模块化增强子:顺式调控进化中的新问题
我们对顺式调控元件工作原理的理解进展迅速,超过了我们的进化模型。在这篇综述中,我们将探讨新的机理发现对进化发育生物学的影响。我们将重点讨论三个不同的问题:进化创新是更多地通过修改旧的顺式调控元件还是出现新的顺式调控元件来实现;单个元件在多大程度上是特异和自主的,还是多功能和相互依存的;顺式调控结构的稳健性如何影响性状进化的速度。这些讨论使我们对顺式调控的进化演变提出了新的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Trends in ecology & evolution
Trends in ecology & evolution 生物-进化生物学
CiteScore
26.50
自引率
3.00%
发文量
178
审稿时长
6-12 weeks
期刊介绍: Trends in Ecology & Evolution (TREE) is a comprehensive journal featuring polished, concise, and readable reviews, opinions, and letters in all areas of ecology and evolutionary science. Catering to researchers, lecturers, teachers, field workers, and students, it serves as a valuable source of information. The journal keeps scientists informed about new developments and ideas across the spectrum of ecology and evolutionary biology, spanning from pure to applied and molecular to global perspectives. In the face of global environmental change, Trends in Ecology & Evolution plays a crucial role in covering all significant issues concerning organisms and their environments, making it a major forum for life scientists.
期刊最新文献
Pollinator cognition and the function of complex rewards. Ecological debts induced by heat extremes. Sex-specific variation in species interactions matters in ecological communities. An audacious approach to conservation. Animals in restoration to achieve climate biodiversity targets.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1