Modified Montmorillonite Catalysed Ultrasonic Assisted one-pot Synthesis of Novel 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7H)-ones as Potential Anticancer Agents

IF 2.1 4区 化学 Q3 CHEMISTRY, PHYSICAL Catalysis Surveys from Asia Pub Date : 2024-09-09 DOI:10.1007/s10563-024-09435-0
Samika Anand, Sunaja Devi K. R., Santhosh Govindaraju, Sumaiya Tabassum
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Abstract

The development of novel compounds with potential anticancer activity is imperative for combating the challenges posed by cancer. In this study, a modified montmorillonite based catalyst is employed for the synthesis of 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7 H)-ones, which are promising candidates for anticancer agents. Montmorillonite is modified using mixed metal oxides, typically Al2O3 and CeO2, by a facile approach followed by standard spectroscopic and electron microscopic characterizations. It is then employed for the one-pot synthesis of a series of 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7 H)-ones. The synthesis protocol, mediated by ultrasound, is simple, efficient, and environment friendly. The mixed metal oxide pillared montmorillonite catalyst exhibits high catalytic activity and selectivity, facilitating the formation of the desired compounds in good to excellent yields. The synthesized compounds are characterized using various spectroscopic techniques such as 1H NMR, 13C NMR and mass spectrometry. Furthermore, the anticancer activity of the synthesized compounds is evaluated against a series of cancer cell lines, revealing promising cytotoxic effects. The findings of this study highlight the potential of novel 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7 H)-ones as promising anticancer agent, warranting further investigation for their therapeutic potential.

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改性蒙脱石催化超声辅助单锅合成新型 2,3-二氢异恶唑并[5,4-d] 嘧啶-4(7H)-酮作为潜在的抗癌剂
开发具有潜在抗癌活性的新型化合物是应对癌症挑战的当务之急。在本研究中,使用了一种基于改性蒙脱石的催化剂来合成 2,3-二氢异恶唑并[5,4-d] 嘧啶-4(7H)-酮,它们是很有希望的候选抗癌剂。使用混合金属氧化物(通常是 Al2O3 和 CeO2)对蒙脱石进行改性是一种简便的方法,然后进行标准的光谱和电子显微镜表征。然后利用它进行一系列 2,3-二氢异恶唑并[5,4-d] 嘧啶-4(7H)-酮的一锅合成。该合成方案以超声为介导,简单、高效、环保。混合金属氧化物柱状蒙脱石催化剂表现出很高的催化活性和选择性,促进了所需化合物的生成,而且产率从良好到极佳。合成的化合物通过各种光谱技术(如 1H、13C、NMR 和质谱)进行了表征。此外,还评估了合成化合物对一系列癌细胞系的抗癌活性,结果显示这些化合物具有良好的细胞毒性作用。本研究的结果凸显了新型 2,3-二氢异恶唑并[5,4-d] 嘧啶-4(7H)-酮作为抗癌剂的潜力,值得进一步研究其治疗潜力。
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来源期刊
Catalysis Surveys from Asia
Catalysis Surveys from Asia 化学-物理化学
CiteScore
4.80
自引率
0.00%
发文量
29
审稿时长
>12 weeks
期刊介绍: Early dissemination of important findings from Asia which may lead to new concepts in catalyst design is the main aim of this journal. Rapid, invited, short reviews and perspectives from academia and industry will constitute the major part of Catalysis Surveys from Asia . Surveys of recent progress and activities in catalytic science and technology and related areas in Asia will be covered regularly as well. We would appreciate critical comments from colleagues throughout the world about articles in Catalysis Surveys from Asia . If requested and thought appropriate, the comments will be included in the journal. We will be very happy if this journal stimulates global communication between scientists and engineers in the world of catalysis.
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