Preparation and biocompatibility of collagen surface-modified styrene-isobutylene-styrene

Abstract

Styrene-Isobutylene-Styrene (SIBS) is a high-performance biocompatible elastomeric material. However, its low surface energy and hydrophobic nature limit its widespread application in the field of implantable materials within the human body. In this study, UV-initiated polymerization was employed to prepare SIBS-acrylic acid surface-grafted co-polymer. Subsequently, collagen protein (Coll) surface modification of SIBS was achieved through a coupling reaction with acrylic acid, resulting in the production of Collagen Surface-Modified SIBS, denoted as SIBS-AA-Coll. Characterization was carried out using techniques such as infrared spectroscopy, thermal analysis, scanning electron microscopy, X-ray photoelectron spectroscopy (XPS), and water contact angle measurements. The results demonstrated that, with a UV exposure time of 4 min and a n_BP:n_AA ratio of 15:100, the grafting ratio reached 9.4%, significantly improving the hydrophilicity of the SIBS surface. In vitro cytotoxicity tests and in vivo animal implantation experiments indicated that Collagen Surface-Modified SIBS exhibited excellent biocompatibility.