Enantioselective Oxidative Homocoupling of 2-Oxindoles with a Chiral Bisguanidinium Hypoiodite Catalyst

IF 1.7 4区 化学 Q3 CHEMISTRY, ORGANIC Synlett Pub Date : 2024-08-20 DOI:10.1055/s-0043-1775056
Minami Odagi, Yuta Shimizu, Kota Sugimoto, Io Mori, Ban Xu, Choon Hong Tan, Kazuo Nagasawa
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Abstract

The bisoxindole motif is present in a variety of biologically active compounds. Here, we report an enantioselective oxidative homocoupling reaction of 2-oxindoles in the presence of a chiral bisguanidinium hypoiodite catalyst, providing access to the corresponding optically active bisoxindoles in excellent yields and with moderate to high diastereo- and enantioselectivities.

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用手性次碘酸双胍催化剂对 2-氧化吲哚进行对映选择性氧化偶联反应
双吲哚基团存在于多种具有生物活性的化合物中。在此,我们报告了在手性双胍基次碘酸催化剂存在下,2-氧化吲哚的对映体选择性氧化同偶联反应,以优异的产率和中等至高的非对映及对映体选择性获得了相应的光学活性双氧化吲哚。
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来源期刊
Synlett
Synlett 化学-有机化学
CiteScore
3.40
自引率
5.00%
发文量
369
审稿时长
1 months
期刊介绍: SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.
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