Association of Estrogen Receptor-α and Aryl Hydrocarbon Receptor Gene Polymorphisms with Ischemic Stroke in an Egyptian Population: A Pilot Study

IF 2.8 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Molecular Neuroscience Pub Date : 2024-09-12 DOI:10.1007/s12031-024-02255-x
Sara A. Aboelroos, Dina Gamal El Segaey, Amr Kamal Abd Elgawad, Marwa Orabi, Marwa Hussein Mohamed, Nashwa R. Hassan
{"title":"Association of Estrogen Receptor-α and Aryl Hydrocarbon Receptor Gene Polymorphisms with Ischemic Stroke in an Egyptian Population: A Pilot Study","authors":"Sara A. Aboelroos,&nbsp;Dina Gamal El Segaey,&nbsp;Amr Kamal Abd Elgawad,&nbsp;Marwa Orabi,&nbsp;Marwa Hussein Mohamed,&nbsp;Nashwa R. Hassan","doi":"10.1007/s12031-024-02255-x","DOIUrl":null,"url":null,"abstract":"<div><p>Stroke is the second leading cause of death and a major contributor to disability worldwide, with the highest prevalence in developing countries. Ischemic stroke (IS) is a complex disease resulting from genetic and environmental interactions. The present work is a pilot study exploring the association of estrogen receptor-α (<i>ESR1</i>) and aryl hydrocarbon receptor (<i>AHR</i>) SNPs with IS in a small Egyptian population of IS patients. Sixty IS patients and 60 matched healthy controls were included in this case–control study. Genotyping of <i>ESR1</i> PvuII (rs2234693), <i>ESR1</i> XbaI (rs9340799), and <i>AHR</i> rs2066853 SNPs was performed using real-time PCR. <i>ESR1</i> PvuII TC and CC genotypes were associated with IS (odds ratio (OR) = 2.821, 95% confidence interval (CI) = 1.204–6.609, <i>p</i> = 0.017, and OR = 9.455, 95% CI = 2.222–40.237, <i>p</i> = 0.002, respectively), and TC genotype in female IS (OR = 4.018, 95% CI = 1.117–14.455, <i>p</i> = 0.033). Additionally, <i>ESR1</i> XbaI GA and GG genotypes were associated with IS (OR = 2.833, 95% CI = 1.190–6.749, <i>p</i> = 0.019, and OR = 34.000, 95% CI = 6.965–165.980, <i>p</i> &lt; 0.001, respectively), and the AG and GG genotypes in male IS (OR = 3.378, 95% CI = 1.103–10.347, <i>p</i> = 0.033 and OR = 22.8, 95% CI = 2.580–201.488, <i>p</i> = 0.005, respectively) and the GG genotype in female IS (95% CI = 7.259–1115.914, <i>p</i> &lt; 0.001). <i>ESR1</i> PvuII and XbaI haplotypes C—A, T—G, and C—A increased the risk of IS in both genders, in male IS, and in female IS apart from C—A. The AG genotype of <i>AHR</i> rs2066853 was associated with male IS (OR = 6.900, 95% CI = 2.120–22.457 <i>p</i> = 0.001). <i>ESR1</i> PvuII, <i>ESR1</i> XbaI, and <i>AHR</i> rs2066853 SNPs are associated with IS in Egyptians. However, this is a small sample, and the findings should be replicated in a larger population.</p></div>","PeriodicalId":652,"journal":{"name":"Journal of Molecular Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12031-024-02255-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Stroke is the second leading cause of death and a major contributor to disability worldwide, with the highest prevalence in developing countries. Ischemic stroke (IS) is a complex disease resulting from genetic and environmental interactions. The present work is a pilot study exploring the association of estrogen receptor-α (ESR1) and aryl hydrocarbon receptor (AHR) SNPs with IS in a small Egyptian population of IS patients. Sixty IS patients and 60 matched healthy controls were included in this case–control study. Genotyping of ESR1 PvuII (rs2234693), ESR1 XbaI (rs9340799), and AHR rs2066853 SNPs was performed using real-time PCR. ESR1 PvuII TC and CC genotypes were associated with IS (odds ratio (OR) = 2.821, 95% confidence interval (CI) = 1.204–6.609, p = 0.017, and OR = 9.455, 95% CI = 2.222–40.237, p = 0.002, respectively), and TC genotype in female IS (OR = 4.018, 95% CI = 1.117–14.455, p = 0.033). Additionally, ESR1 XbaI GA and GG genotypes were associated with IS (OR = 2.833, 95% CI = 1.190–6.749, p = 0.019, and OR = 34.000, 95% CI = 6.965–165.980, p < 0.001, respectively), and the AG and GG genotypes in male IS (OR = 3.378, 95% CI = 1.103–10.347, p = 0.033 and OR = 22.8, 95% CI = 2.580–201.488, p = 0.005, respectively) and the GG genotype in female IS (95% CI = 7.259–1115.914, p < 0.001). ESR1 PvuII and XbaI haplotypes C—A, T—G, and C—A increased the risk of IS in both genders, in male IS, and in female IS apart from C—A. The AG genotype of AHR rs2066853 was associated with male IS (OR = 6.900, 95% CI = 2.120–22.457 p = 0.001). ESR1 PvuII, ESR1 XbaI, and AHR rs2066853 SNPs are associated with IS in Egyptians. However, this is a small sample, and the findings should be replicated in a larger population.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
埃及人群中雌激素受体-α和芳香烃受体基因多态性与缺血性中风的关系:一项试点研究
中风是全球第二大死因,也是导致残疾的主要因素,在发展中国家发病率最高。缺血性中风(IS)是一种由遗传和环境相互作用导致的复杂疾病。本研究是一项探索雌激素受体-α(ESR1)和芳基烃受体(AHR)SNPs 与缺血性中风关系的试验性研究。这项病例对照研究纳入了 60 名 IS 患者和 60 名匹配的健康对照者。采用实时 PCR 对 ESR1 PvuII(rs2234693)、ESR1 XbaI(rs9340799)和 AHR rs2066853 SNPs 进行了基因分型。ESR1 PvuII TC和CC基因型与IS相关(几率比(OR)= 2.821,95%置信区间(CI)= 1.204-6.609,p = 0.017;OR = 9.455,95% CI = 2.222-40.237,p = 0.002),女性IS的TC基因型与IS相关(OR = 4.018,95% CI = 1.117-14.455,p = 0.033)。此外,ESR1 XbaI GA和GG基因型与IS相关(分别为OR = 2.833,95% CI = 1.190-6.749,p = 0.019和OR = 34.000,95% CI = 6.965-165.980,p <0.001),男性IS中的AG和GG基因型与IS相关(OR = 3.378,95% CI = 1.103-10.347,p = 0.033 和 OR = 22.8,95% CI = 2.580-201.488,p = 0.005),以及女性 IS 中的 GG 基因型(95% CI = 7.259-1115.914,p <0.001)。ESR1的PvuII和XbaI单倍型C-A、T-G和C-A增加了男女两性、男性IS和女性IS(C-A除外)的IS风险。AHR rs2066853 的 AG 基因型与男性 IS 相关(OR = 6.900,95% CI = 2.120-22.457 p = 0.001)。ESR1 PvuII、ESR1 XbaI和AHR rs2066853 SNP与埃及人的IS有关。然而,这只是一个小样本,研究结果应在更大的人群中重复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Molecular Neuroscience
Journal of Molecular Neuroscience 医学-神经科学
CiteScore
6.60
自引率
3.20%
发文量
142
审稿时长
1 months
期刊介绍: The Journal of Molecular Neuroscience is committed to the rapid publication of original findings that increase our understanding of the molecular structure, function, and development of the nervous system. The criteria for acceptance of manuscripts will be scientific excellence, originality, and relevance to the field of molecular neuroscience. Manuscripts with clinical relevance are especially encouraged since the journal seeks to provide a means for accelerating the progression of basic research findings toward clinical utilization. All experiments described in the Journal of Molecular Neuroscience that involve the use of animal or human subjects must have been approved by the appropriate institutional review committee and conform to accepted ethical standards.
期刊最新文献
Antisecretory Factor 16 (AF16): A Promising Avenue for the Treatment of Traumatic Brain Injury—An In Vitro Model Approach Sex Differences in Blood Accumulation of Neurodegenerative-Related Proteins and Antioxidant Responses to Regular Physical Exercise A Ketogenic Diet Affects Gut Microbiota by Regulating Gut Microbiota and Promoting Hippocampal TRHR Expression to Combat Seizures The Deficiency of the ASD-Related Gene CHD8 Disrupts Behavioral Patterns and Inhibits Hippocampal Neurogenesis in Mice The Role of Non-Coding RNAs in Mitochondrial Dysfunction of Alzheimer’s Disease
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1