{"title":"Bioimpedance a Diagnostic Tool for Tobacco Induced Oral Lesions: a Mixed Model cross-sectional study","authors":"Vaibhav Gupta, Poonam Goel, Usha Agrawal, Neena Chaudhary, Garima Jain, Deepak Gupta","doi":"arxiv-2408.11886","DOIUrl":null,"url":null,"abstract":"Introduction: Electrical impedance spectroscopy (EIS) has recently developed\nas a novel diagnostic device for screening and evaluating cervical dysplasia,\nprostate cancer, breast cancer and basal cell carcinoma. The current study\naimed to validate and evaluate bioimpedance as a diagnostic tool for\ntobacco-induced oral lesions. Methodology: The study comprised 50 OSCC and OPMD\ntissue specimens for in-vitro study and 320 subjects for in vivo study.\nBioimpedance device prepared and calibrated. EIS measurements were done for the\nhabit and control groups and were compared. Results: The impedance value in the\ncontrol group was significantly higher compared to the OPMD and OSCC groups.\nDiagnosis based on BIS measurements has a sensitivity of 95.9% and a\nspecificity of 86.7%. Conclusion: Bioimpedance device can help in\ndecision-making for differentiating OPMD and OSCC cases and their management,\nespecially in primary healthcare settings. Keywords: Impedance, Cancer, Diagnosis, Device, Community","PeriodicalId":501266,"journal":{"name":"arXiv - QuanBio - Quantitative Methods","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv - QuanBio - Quantitative Methods","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/arxiv-2408.11886","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Electrical impedance spectroscopy (EIS) has recently developed
as a novel diagnostic device for screening and evaluating cervical dysplasia,
prostate cancer, breast cancer and basal cell carcinoma. The current study
aimed to validate and evaluate bioimpedance as a diagnostic tool for
tobacco-induced oral lesions. Methodology: The study comprised 50 OSCC and OPMD
tissue specimens for in-vitro study and 320 subjects for in vivo study.
Bioimpedance device prepared and calibrated. EIS measurements were done for the
habit and control groups and were compared. Results: The impedance value in the
control group was significantly higher compared to the OPMD and OSCC groups.
Diagnosis based on BIS measurements has a sensitivity of 95.9% and a
specificity of 86.7%. Conclusion: Bioimpedance device can help in
decision-making for differentiating OPMD and OSCC cases and their management,
especially in primary healthcare settings. Keywords: Impedance, Cancer, Diagnosis, Device, Community
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