EVALUATON OF INFLAMMATION WITH CRP, IL-1, PRO-BNP, LEPTIN AND PETRAXIN -3 LEVELS IN OBESITY-RELATED HYPERTENSION

Abstract

Background: The studies examining the relationship between hypertension, obesity and inflammation are increasing. It is suggested that markers of inflammation may predict obesity-related hypertension.Objective: The aim of study is to determine the relationship between the inflammation and the severity of hypertension with the inflammation biomarkers including CRP, IL-1, pro-BNP, leptin, pentraxin-3 levels in children with obesity-related hypertension.Material and Methods: This cross-sectional study involved patients diagnosed with obesity-related hypertension and healthy children. The sociodemographic data, anthropometric measurements, blood pressure, 24-hour ambulatory blood pressure, and echocardiographic findings were recorded. IL-1, CRP, leptin, pro-BNP, and pentraxin-3 levels were measured in the venous blood sample taken from the patient and control groups.Results: Systolic blood pressure, diastolic blood pressure, height, weight, body mass index were statistically significantly higher in the patient group than the healthy controls. In patient group, echocardiographic examination revealed findings confirming left ventricular hypertrophy. CRP (p=0.041) and leptin (p<0.001) levels of the patient group were found to be significantly higher than the control group. There was no significant difference between the groups in terms of pentraxin-3 (p=0.917), IL-1 (p=0.981), and pro-BNP (p=0.288) levels. We found that there was a moderate positive correlation between leptin and systolic blood pressure in healthy children, moderately strong correlations between Pro-BNP and systolic blood pressure in the negative corelation, and a weak positive correlation between leptin and diastolic blood pressure in obesity group.