Association Between Life's Essential 8 and Atherogenic Index of Plasma in Adults: Insights from NHANES 2007-2018

Longhui Xu, Kai-wen Ding, Guo-dong Yang, Xiao-xuan Han, Xiao Cong, Rong-hui Wang, Xin-ru Liu, Na Li, Cui-ping Xu
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Abstract

Objectives: This study aimed to investigate the relationship between Life's Essential 8 (LE8) and the Atherogenic Index of Plasma (AIP). Methods: We conducted an analysis of data from 8,215 U.S. adults aged 20 years and older, utilizing the National Health and Nutrition Examination Survey data from 2007 to 2018. Based on LE8 scores, Cardiovascular Health (CVH) was stratified into three levels—low, moderate, and high—while AIP was categorized into four risk levels: extremely low (AIP<-0.3), low (-0.3≤AIP<0.1), medium (0.1≤AIP<0.24), and high (AIP≤0.24). Weighted ordinal logistic regression analysis was utilized to examine the association between CVH scores and AIP risk levels, adjusting for potential confounding variables. Results: A significant inverse correlation exists between CVH scores and AIP risk levels (OR=0.51, 95%CI: 0.49-0.54, P<0.001). Higher CVH scores were associated with lower AIP risk levels, while lower CVH scores corresponded to elevated AIP risk levels. Notably, improvements in specific CVH components such as Body Mass Index and Blood Lipids exhibited a strong relationship with reductions in AIP risk levels. Conclusions: Enhancing CVH is vital for effectively reducing AIP risk levels, thus underscoring the critical importance of health management strategies in the prevention of cardiovascular diseases.
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成人生活必需品 8 与血浆致动脉粥样硬化指数之间的关系:从 2007-2018 年国家健康调查(NHANES)中获得的启示
研究目的本研究旨在调查生活必备八项(LE8)与血浆致动脉粥样硬化指数(AIP)之间的关系:我们利用 2007 年至 2018 年的美国国家健康与营养调查数据,对 8215 名 20 岁及以上美国成年人的数据进行了分析。根据 LE8 分数,心血管健康(CVH)被分为三个等级--低、中、高,而 AIP 被分为四个风险等级:极低(AIP<-0.3)、低(-0.3≤AIP<0.1)、中(0.1≤AIP<0.24)和高(AIP≤0.24)。利用加权序数逻辑回归分析来研究 CVH 评分与 AIP 风险水平之间的关系,并对潜在的混杂变量进行了调整。结果显示CVH 评分与 AIP 风险水平之间存在明显的反相关性(OR=0.51,95%CI:0.49-0.54,P<0.001)。CVH得分越高,AIP风险水平越低,而CVH得分越低,AIP风险水平越高。值得注意的是,身体质量指数和血脂等特定 CVH 成分的改善与 AIP 风险水平的降低有密切关系。结论:提高 CVH 对有效降低 AIP 风险水平至关重要,因此强调了健康管理策略在预防心血管疾病中的极端重要性。
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