Ying Qing, Jianheng Zheng, Meng Qin, Xiufen Liu, Zhao Dai, Xinyue Xu, Yingyi Luo, Shichun Li, Liqiang Wang, Shuyu Yang, Jun Du, Ying Lu, Yanfei Li
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引用次数: 0
Abstract
Trace element levels in the circulation (blood, serum, plasma) are believed to play a role in the pathophysiologic processes of Alzheimer’s disease (AD); however, there is heterogeneity in the available findings. This study conducted a systematic review and meta-analysis of trace elements (including: copper (Cu), iron (Fe), zinc (Zn), selenium (Se), lead (Pb), cadmium (Cd), mercury (Hg), manganese (Mn), aluminum (Al), arsenic (As), and magnesium (Mg)) in AD patients and controls to assess the variation of trace elements in the circulation of AD patients. By systematically screening case–control studies on circulatory trace element levels in AD patients from 2000 to the present in the PubMed, Web of Science, and MEDLINE databases, 52 studies were included in the final meta-analysis. The results of the random-effects model showed significantly elevated circulatory levels of Cd (SMD = 0.79, 95% CI: 0.35, 1.24), Hg (SMD = 0.59, 95% CI: 0.03, 1.16), and Cu (SMD = 0.70, 95% CI: 0.37, 1.04) in AD patients, while levels of Fe (SMD = − 0.58, 95% CI: − 1.03, − 0.13), Se (SMD = − 0.53, 95% CI: − 0.85, − 0.21), and Zn (SMD = − 0.99, 95% CI: − 1.52, − 0.46) were significantly lower. The database formed in this study provides reliable population-based research evidence for exploring changes in circulating trace element levels in AD patients. Monitoring and stabilization of circulatory trace element levels in the elderly may be a potential preventive target for AD.
期刊介绍:
ESEU is an international journal, focusing primarily on Europe, with a broad scope covering all aspects of environmental sciences, including the main topic regulation.
ESEU will discuss the entanglement between environmental sciences and regulation because, in recent years, there have been misunderstandings and even disagreement between stakeholders in these two areas. ESEU will help to improve the comprehension of issues between environmental sciences and regulation.
ESEU will be an outlet from the German-speaking (DACH) countries to Europe and an inlet from Europe to the DACH countries regarding environmental sciences and regulation.
Moreover, ESEU will facilitate the exchange of ideas and interaction between Europe and the DACH countries regarding environmental regulatory issues.
Although Europe is at the center of ESEU, the journal will not exclude the rest of the world, because regulatory issues pertaining to environmental sciences can be fully seen only from a global perspective.