The diagnosis performance of [18F]FDG PET/CT, MRI, and CT in the diagnosis of mandibular invasion in oral/oropharyngeal carcinoma: a head-to-head comparative meta-analysis

IF 2.3 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Clinical and Translational Imaging Pub Date : 2024-08-26 DOI:10.1007/s40336-024-00657-w

Siqi Zhao, Xiao Li

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Abstract

Purpose

This research synthesis investigates the diagnostic performance of [¹⁸F]FDG PET/CT, MRI, and CT in detecting mandibular invasion in patients with oral and oropharyngeal cancer.

Methods

An extensive literature review was conducted using PubMed and Embase, targeting studies up to March 2024 that examined the diagnostic capabilities of [¹⁸F]FDG PET/CT, MRI, and CT for oral and oropharyngeal cancer patients. Sensitivity and specificity were calculated using the DerSimonian and Laird random-effects model with adjustments via the Freeman-Tukey double arc sine transformation. Study quality was assessed with the QUADAS-2 tool.

Results

This meta-analysis synthesized data from 24 studies involving 1376 participants to compare the diagnostic performance of CT, MRI, and [¹⁸F]FDG PET/CT for mandibular invasion in oral and oropharyngeal cancer patients. The results showed closely matched sensitivity and specificity among the technologies: CT pooled a sensitivity of 0.80 and specificity of 0.85, while MRI exhibited a slightly better sensitivity at 0.87 but lower specificity at 0.81, with the differences not reaching statistical significance (all P > 0.05). [¹⁸F]FDG PET/CT also demonstrated comparable performance, achieving a sensitivity of 0.77 versus CT’s 0.72 and a specificity of 0.82 versus CT’s 0.93, alongside matching MRI’s sensitivity at 0.86 and a specificity of 0.68 versus MRI’s 0.75, with all comparisons showing no significant disparities (all P > 0.05).

Conclusions

The meta-analysis concludes that there was no statistically significant difference in diagnostic performance between [¹⁸F]FDG PET/CT, CT and MRI. Further research with prospective comparative trials is recommended to validate these findings in new clinical cohorts.

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[18F]FDG正电子发射计算机断层显像/计算机断层扫描、核磁共振成像和计算机断层扫描在诊断口腔癌/咽癌下颌骨侵犯中的诊断效果：头对头比较荟萃分析

目的本研究综述调查了[18F]FDG PET/CT、MRI和CT在检测口腔癌和口咽癌患者下颌骨侵犯方面的诊断性能。方法使用PubMed和Embase进行了广泛的文献综述，目标是2024年3月之前对口腔癌和口咽癌患者的[18F]FDG PET/CT、MRI和CT诊断能力进行检查的研究。灵敏度和特异性采用 DerSimonian 和 Laird 随机效应模型计算，并通过 Freeman-Tukey 双弧正弦变换进行调整。结果这项荟萃分析综合了24项研究的数据，涉及1376名参与者，比较了CT、MRI和[18F]FDG PET/CT对口腔癌和口咽癌患者下颌骨侵犯的诊断性能。结果显示，这些技术的灵敏度和特异性非常接近：CT 的灵敏度为 0.80，特异性为 0.85，而 MRI 的灵敏度稍高，为 0.87，但特异性较低，为 0.81，差异未达到统计学意义（所有 P 均为 0.05）。[18F]FDG正电子发射计算机断层显像/计算机断层扫描（PET/CT）也表现出相当的性能，灵敏度为0.77，而CT为0.72；特异性为0.82，而CT为0.93；与此同时，MRI的灵敏度为0.86，而MRI为0.75；特异性为0.68，而MRI为0.75，所有比较均未显示出显著差异（所有P均为0.05）。建议进一步开展前瞻性比较试验研究，以便在新的临床队列中验证这些发现。

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来源期刊

Clinical and Translational Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

3.60

自引率

4.80%

发文量

期刊介绍： Clinical and Translational Imaging is an international journal that publishes timely, up-to-date summaries on clinical practice and translational research and clinical applications of approved and experimental radiopharmaceuticals for diagnostic and therapeutic purposes. Coverage includes such topics as advanced preclinical evidence in the fields of physics, dosimetry, radiation biology and radiopharmacy with relevance to applications in human subjects. The journal benefits a readership of nuclear medicine practitioners and allied professionals involved in molecular imaging and therapy.