Magnetic and radio frequency dual-responsive shape-programmable robots for adaptive aneurysm embolization

IF 7.9 2区综合性期刊 Q1 CHEMISTRY, MULTIDISCIPLINARY Cell Reports Physical Science Pub Date : 2024-08-20 DOI:10.1016/j.xcrp.2024.102160

Jiancheng Liu, Shu Wang, Shunyuan Huang, Ke Zhang, , Zhecheng Chen, Chenyang Huang, Yonghong Zhang, Shiwei Du, Tiantian Xu

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Abstract

Aneurysm is a common disease that poses a threat to human health. Currently, treating aneurysms mainly relies on embolization using metallic microcoils. However, it is extremely difficult to insert metallic microcoils into the aneurysm inside tortuous vessels. Besides, adapting fixed metallic microcoils to different aneurysms is also a major problem. In this paper, we propose a shape-programmable robot based on a magnetic and radio frequency (RF) dual-responsive shape memory polymer (SMP). The SMP robot can move automatically to the target under a programmable magnetic field. Meanwhile, it can be heated up and will transform from a small-sized ball shape to the aneurysm shape using RF. In addition, the dual-responsive SMP has excellent mechanical properties; its tensile modulus is 50 times higher than that of traditional hydrogels, reducing the possibility of fracture during embolization. In the future, this SMP robot could be potentially suitable for clinical translation.

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用于自适应动脉瘤栓塞的磁性和射频双响应形状可编程机器人

动脉瘤是一种威胁人类健康的常见疾病。目前，治疗动脉瘤主要依靠使用金属微线圈进行栓塞。然而，将金属微线圈插入迂曲血管内的动脉瘤极为困难。此外，如何使固定的金属微线圈适应不同的动脉瘤也是一大难题。在本文中，我们提出了一种基于磁性和射频（RF）双响应形状记忆聚合物（SMP）的形状可编程机器人。在可编程磁场的作用下，SMP 机器人可以自动移动到目标位置。同时，它可以加热，并利用射频从小球形状转变为动脉瘤形状。此外，双响应 SMP 还具有出色的机械性能，其拉伸模量是传统水凝胶的 50 倍，降低了栓塞过程中断裂的可能性。未来，这种SMP机器人有望应用于临床。

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来源期刊

Cell Reports Physical Science Energy-Energy (all)

CiteScore

11.40

自引率

2.20%

发文量

388

审稿时长

62 days

期刊介绍： Cell Reports Physical Science, a premium open-access journal from Cell Press, features high-quality, cutting-edge research spanning the physical sciences. It serves as an open forum fostering collaboration among physical scientists while championing open science principles. Published works must signify significant advancements in fundamental insight or technological applications within fields such as chemistry, physics, materials science, energy science, engineering, and related interdisciplinary studies. In addition to longer articles, the journal considers impactful short-form reports and short reviews covering recent literature in emerging fields. Continually adapting to the evolving open science landscape, the journal reviews its policies to align with community consensus and best practices.