{"title":"Magnetically powered cancer cell microrobots for surgery-free generation of targeted tumor mouse models","authors":"Zehao Wu, Heng Sun, Zichen Xu, Kai Feng, Josh Haipeng Lei, Chu-Xia Deng, Qingsong Xu","doi":"10.1016/j.xcrp.2024.102182","DOIUrl":null,"url":null,"abstract":"<p>In precision therapy, patient-derived cancer cells are inoculated into the same organ from which they are derived to simulate the microenvironment of the original tumor. However, due to the high technical difficulty and low success rate of the required surgical operation, appropriate animal models are lacking, which restricts its application. Here, we report a surgery-free method for creating a desired tumor mouse model using cancer cell microrobots guided by rotating gradient magnetic fields. The uptake of magnetic particles produces cancer cell microrobots. The external magnetic field enables the microrobots to hover around the target localization, enhancing their ability to penetrate the vascular endothelium. <em>In vivo</em> tests in mice demonstrate the capability of creating a desired tumor mass in a particular body location. This work provides a promising method to generate a targeted tumor mouse model without using conventional surgery operations for further precision medicine treatment study of cancer.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"30 1","pages":""},"PeriodicalIF":7.9000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Reports Physical Science","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1016/j.xcrp.2024.102182","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
In precision therapy, patient-derived cancer cells are inoculated into the same organ from which they are derived to simulate the microenvironment of the original tumor. However, due to the high technical difficulty and low success rate of the required surgical operation, appropriate animal models are lacking, which restricts its application. Here, we report a surgery-free method for creating a desired tumor mouse model using cancer cell microrobots guided by rotating gradient magnetic fields. The uptake of magnetic particles produces cancer cell microrobots. The external magnetic field enables the microrobots to hover around the target localization, enhancing their ability to penetrate the vascular endothelium. In vivo tests in mice demonstrate the capability of creating a desired tumor mass in a particular body location. This work provides a promising method to generate a targeted tumor mouse model without using conventional surgery operations for further precision medicine treatment study of cancer.
期刊介绍:
Cell Reports Physical Science, a premium open-access journal from Cell Press, features high-quality, cutting-edge research spanning the physical sciences. It serves as an open forum fostering collaboration among physical scientists while championing open science principles. Published works must signify significant advancements in fundamental insight or technological applications within fields such as chemistry, physics, materials science, energy science, engineering, and related interdisciplinary studies. In addition to longer articles, the journal considers impactful short-form reports and short reviews covering recent literature in emerging fields. Continually adapting to the evolving open science landscape, the journal reviews its policies to align with community consensus and best practices.