{"title":"Shared challenges to the control of complex intracellular neglected pathogens","authors":"Rebecca Lynn Perez, Jemima Chase, Rachel Tanner","doi":"10.3389/fpubh.2024.1423420","DOIUrl":null,"url":null,"abstract":"The complex intracellular pathogens <jats:italic>Mycobacterium tuberculosis</jats:italic>, <jats:italic>Mycobacterium leprae</jats:italic>, <jats:italic>Leishmania</jats:italic> spp., and <jats:italic>Burkholderia pseudomallei</jats:italic>, which cause tuberculosis, leprosy, leishmaniasis, and melioidosis respectively, represent major health threats with a significant global burden concentrated in low- and middle-income countries. While these diseases vary in their aetiology, pathology and epidemiology, they share key similarities in the biological and sociodemographic factors influencing their incidence and impact worldwide. In particular, their occurrence in resource-limited settings has important implications for research and development, disease prevalence and associated risk factors, as well as access to diagnostics and therapeutics. In accordance with the vision of the VALIDATE (VAccine deveLopment for complex Intracellular neglecteD pAThogeEns) Network, we consider shared challenges to the effective prevention, diagnosis and treatment of these diseases as shaped by both biological and social factors, illustrating the importance of taking an interdisciplinary approach. We further highlight how a cross-pathogen perspective may provide valuable insights for understanding and addressing challenges to the control of all four pathogens.","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fpubh.2024.1423420","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
Abstract
The complex intracellular pathogens Mycobacterium tuberculosis, Mycobacterium leprae, Leishmania spp., and Burkholderia pseudomallei, which cause tuberculosis, leprosy, leishmaniasis, and melioidosis respectively, represent major health threats with a significant global burden concentrated in low- and middle-income countries. While these diseases vary in their aetiology, pathology and epidemiology, they share key similarities in the biological and sociodemographic factors influencing their incidence and impact worldwide. In particular, their occurrence in resource-limited settings has important implications for research and development, disease prevalence and associated risk factors, as well as access to diagnostics and therapeutics. In accordance with the vision of the VALIDATE (VAccine deveLopment for complex Intracellular neglecteD pAThogeEns) Network, we consider shared challenges to the effective prevention, diagnosis and treatment of these diseases as shaped by both biological and social factors, illustrating the importance of taking an interdisciplinary approach. We further highlight how a cross-pathogen perspective may provide valuable insights for understanding and addressing challenges to the control of all four pathogens.
结核分枝杆菌、麻风分枝杆菌、利什曼原虫和假马勒伯克霍尔德氏菌是复杂的细胞内病原体,它们分别导致结核病、麻风病、利什曼病和类鼻疽,对健康构成重大威胁,给全球造成的沉重负担主要集中在中低收入国家。虽然这些疾病的病因、病理和流行病学各不相同,但它们在影响其发病率和对全球影响的生物和社会人口因素方面却有着重要的相似之处。特别是,这些疾病发生在资源有限的环境中,对研究和开发、疾病流行和相关风险因素以及诊断和治疗的获取具有重要影响。根据 VALIDATE(VAccine deveLopment for complex Intracellular neglecteD pAThogeEns)网络的愿景,我们认为有效预防、诊断和治疗这些疾病所面临的共同挑战是由生物和社会因素共同决定的,这说明了采取跨学科方法的重要性。我们进一步强调了跨病原体视角如何为理解和应对控制所有四种病原体所面临的挑战提供有价值的见解。
期刊介绍:
Frontiers in Public Health is a multidisciplinary open-access journal which publishes rigorously peer-reviewed research and is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians, policy makers and the public worldwide. The journal aims at overcoming current fragmentation in research and publication, promoting consistency in pursuing relevant scientific themes, and supporting finding dissemination and translation into practice.
Frontiers in Public Health is organized into Specialty Sections that cover different areas of research in the field. Please refer to the author guidelines for details on article types and the submission process.