{"title":"Recent advances of nanozyme-enhanced lateral flow assay sensing in clinic diagnosis","authors":"","doi":"10.1016/j.microc.2024.111602","DOIUrl":null,"url":null,"abstract":"<div><p>Nanozymes have recently garnered significant research attention in biosensing due to their unique properties, including high stability, tunable catalytic activity, and lower production costs than natural enzymes. Lateral flow assays (LFAs) are a representative point-of-care testing (POCT) technique known for their rapid and convenient detection of biological targets in complex matrices. By leveraging their exponential amplification capabilities, nanozymes have been extensively employed in LFA biosensors to enhance analytical sensitivity. This review expounds on recent advancements in nanozyme-based LFAs for clinical diagnosis. It briefly summarizes the working principle and categories of LFAs, classifies nanozymes, and discusses their diagnostic applications for various targets. Finally, the review explores the current challenges and future directions of nanozyme-based LFAs.</p></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":null,"pages":null},"PeriodicalIF":4.9000,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchemical Journal","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0026265X24017144","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Nanozymes have recently garnered significant research attention in biosensing due to their unique properties, including high stability, tunable catalytic activity, and lower production costs than natural enzymes. Lateral flow assays (LFAs) are a representative point-of-care testing (POCT) technique known for their rapid and convenient detection of biological targets in complex matrices. By leveraging their exponential amplification capabilities, nanozymes have been extensively employed in LFA biosensors to enhance analytical sensitivity. This review expounds on recent advancements in nanozyme-based LFAs for clinical diagnosis. It briefly summarizes the working principle and categories of LFAs, classifies nanozymes, and discusses their diagnostic applications for various targets. Finally, the review explores the current challenges and future directions of nanozyme-based LFAs.
期刊介绍：
The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field.
Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.
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