Evaluation of floatability characteristics of gastroretentive tablets using VIS imaging with artificial neural networks

IF 4.4 2区 医学 Q1 PHARMACOLOGY & PHARMACY European Journal of Pharmaceutics and Biopharmaceutics Pub Date : 2024-09-11 DOI:10.1016/j.ejpb.2024.114493
Melinda Kakuk , Lilla Alexandra Mészáros , Dóra Farkas , Péter Tonka-Nagy , Bence Tóth , Zsombor Kristóf Nagy , István Antal , Nikolett Kállai-Szabó
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Abstract

Gastroretentive dosage forms are recommended for several active substances because it is often necessary for the drug to be released from the carrier system into the stomach over an extended period. Among gastroretentive dosage forms, floating tablets are a very popular pharmaceutical technology. In this study, it was investigated whether a rapid, nondestructive method can be used to characterize the floating properties of a tablet.

To accomplish our objective, the same composition was compressed, and varied compression forces were applied to achieve the desired tablet. In addition to physical examinations, digital microscopic images of the tablets were captured and analyzed using image analysis techniques, allowing the investigation of the floatability of the dosage form. Image processing algorithms and artificial neural networks (ANNs) were utilized to classify the samples based on their strength and floatability. The input dataset consisted solely of the acquired images.

It has been shown by our research that visible imaging coupled with pattern recognition neural networks is an efficient way to categorize these samples based on their floatability. Rapid and non-destructive digital imaging of tablet surfaces is facilitated by this method, offering insights into both crushing strength and floating properties.

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利用人工神经网络 VIS 成像评估胃复安片剂的漂浮特性
有几种活性物质推荐使用胃复安剂型,因为药物往往需要从载体系统中长时间释放到胃中。在胃药剂型中,浮动片是一种非常流行的制药技术。为了实现我们的目标,我们对相同的成分进行了压缩,并施加了不同的压缩力以获得所需的片剂。除了物理检查外,我们还利用图像分析技术捕捉和分析了片剂的数字显微图像,从而对剂型的漂浮性进行了研究。利用图像处理算法和人工神经网络(ANN),根据强度和漂浮性对样品进行分类。我们的研究表明,可见光成像与模式识别神经网络相结合,可以有效地根据这些样品的漂浮性对其进行分类。这种方法有助于对片剂表面进行快速、无损的数字成像,从而深入了解压碎强度和漂浮特性。
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来源期刊
CiteScore
8.80
自引率
4.10%
发文量
211
审稿时长
36 days
期刊介绍: The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for the publication of novel, innovative and hypothesis-driven research from the areas of Pharmaceutics and Biopharmaceutics. Topics covered include for example: Design and development of drug delivery systems for pharmaceuticals and biopharmaceuticals (small molecules, proteins, nucleic acids) Aspects of manufacturing process design Biomedical aspects of drug product design Strategies and formulations for controlled drug transport across biological barriers Physicochemical aspects of drug product development Novel excipients for drug product design Drug delivery and controlled release systems for systemic and local applications Nanomaterials for therapeutic and diagnostic purposes Advanced therapy medicinal products Medical devices supporting a distinct pharmacological effect.
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