Apolipoprotein E4 and Alzheimer's disease causality under adverse environments and potential intervention by senolytic nutrients

IF 2.9 Q3 NUTRITION & DIETETICS Clinical nutrition ESPEN Pub Date : 2024-09-07 DOI:10.1016/j.clnesp.2024.09.004

Gabriella C.V. Ciurleo , Orleâncio G.R. de Azevedo , Camila G.M. Carvalho , Michael P. Vitek , Cirle A. Warren , Richard L. Guerrant , Reinaldo B. Oriá

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Abstract

Apolipoprotein E (apoE) has a pivotal role in Alzheimer's Disease (AD) pathophysiology. APOE4 has been recognized as a risk factor for developing late-onset AD. Recently, APOE4 homozygosity was regarded as a new familial genetic trait of AD. In this opinion paper, we summarized the potential pleiotropic antagonism role of APOE4 in children living under early life adversity and afflicted with enteric infection/malnutrition-related pathogenic exposome. APOE4 was found to be neuroprotective early in life despite its increasing risk for AD with aging. We call for awareness of the potential burden this can bring to the public health system when APOE4 carriers, raised under adverse environmental conditions in early life and then aging with unhealthy lifestyles in later life may be at special risk for cognitive impairments and acquired AD. We postulate the importance of anti-senescence therapies to protect these individuals and remediate aging-related chronic illnesses.

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不良环境下载脂蛋白 E4 与阿尔茨海默病的因果关系以及衰老营养素的潜在干预作用

载脂蛋白 E（apoE）在阿尔茨海默病（AD）病理生理学中起着关键作用。APOE4 已被认为是晚发性阿兹海默症的一个风险因素。最近，APOE4同源性被认为是一种新的AD家族遗传特征。在这篇论文中，我们总结了 APOE4 在生活在早期逆境和肠道感染/营养不良相关病原体暴露组的儿童中的潜在多效拮抗作用。研究发现，尽管随着年龄的增长，APOE4 增加了诱发注意力缺失症的风险，但它在生命早期仍具有神经保护作用。我们呼吁，当 APOE4 携带者早年在不利的环境条件下长大，晚年因不健康的生活方式而衰老时，可能会面临认知障碍和获得性 AD 的特殊风险，因此我们应认识到这可能会给公共卫生系统带来的潜在负担。我们推测，抗衰老疗法对于保护这些人和缓解与衰老相关的慢性疾病非常重要。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.