Photothermal-enhanced detoxification metal-organic framework microneedle array for 2-chloroethyl ethyl sulfide-poisoned wound healing

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Materials & Design Pub Date : 2024-09-07 DOI:10.1016/j.matdes.2024.113286

{"title":"Photothermal-enhanced detoxification metal-organic framework microneedle array for 2-chloroethyl ethyl sulfide-poisoned wound healing","authors":"","doi":"10.1016/j.matdes.2024.113286","DOIUrl":null,"url":null,"abstract":"<div><p>Sulfur mustard (2,2′-dichloroethylsulfide; SM) is a bifunctional alkylating agent that can easily penetrate skin and cause persistent pain and damage. Effective biological dressings are required to treat wounds caused or poisoned by SM. Though the use of SM is regulated under the Chemical Weapons Convention, it is still a threat during wars and terrorist attacks. Herein, we present a photothermal-enhanced detoxification microneedles array (MNA) encapsulated with ZnIn<sub>2</sub>S<sub>4</sub>@UiO-66-NH<sub>2</sub> (ZnInS/UIO) catalysts for the treatment of 2-chloroethyl ethyl sulfide (CEES, SM analog)-poisoned wounds under simulated sunlight (SSL) irradiation. Due to the excellent photothermal detoxification capability possessed by ZnInS/UIO, the conversion rate of CEES can be significantly increased under SSL exposure. When encased in a polyvinyl alcohol (PVA) MNA and piercing into the skin, ZnInS/UIO catalysts can be released quickly from MNA for detoxification. After applying the resultant ZnInS/UIO-MNA to the CEES-poisoned wound bed, acceleration of the wound healing process and a reduced inflammatory response can be confirmed. In conclusion, ZnInS/UIO-MNA has encouraging potential as a first-aid dressing for CEES-poisoned wound healing in battlefields and injuries related to acts of terrorism.</p></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":null,"pages":null},"PeriodicalIF":7.6000,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0264127524006610/pdfft?md5=771852b4bbb3d05860800ecd83eaf73c&pid=1-s2.0-S0264127524006610-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials & Design","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0264127524006610","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Sulfur mustard (2,2′-dichloroethylsulfide; SM) is a bifunctional alkylating agent that can easily penetrate skin and cause persistent pain and damage. Effective biological dressings are required to treat wounds caused or poisoned by SM. Though the use of SM is regulated under the Chemical Weapons Convention, it is still a threat during wars and terrorist attacks. Herein, we present a photothermal-enhanced detoxification microneedles array (MNA) encapsulated with ZnIn₂S₄@UiO-66-NH₂ (ZnInS/UIO) catalysts for the treatment of 2-chloroethyl ethyl sulfide (CEES, SM analog)-poisoned wounds under simulated sunlight (SSL) irradiation. Due to the excellent photothermal detoxification capability possessed by ZnInS/UIO, the conversion rate of CEES can be significantly increased under SSL exposure. When encased in a polyvinyl alcohol (PVA) MNA and piercing into the skin, ZnInS/UIO catalysts can be released quickly from MNA for detoxification. After applying the resultant ZnInS/UIO-MNA to the CEES-poisoned wound bed, acceleration of the wound healing process and a reduced inflammatory response can be confirmed. In conclusion, ZnInS/UIO-MNA has encouraging potential as a first-aid dressing for CEES-poisoned wound healing in battlefields and injuries related to acts of terrorism.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

用于 2-氯乙基硫醚中毒伤口愈合的光热增强解毒金属有机框架微针阵列

硫芥子气（2,2′-二氯乙基硫醚；SM）是一种双功能烷化剂，很容易穿透皮肤，造成持续性疼痛和损伤。需要有效的生物敷料来治疗 SM 造成或毒害的伤口。虽然《化学武器公约》对 SM 的使用进行了规定，但它在战争和恐怖袭击中仍是一种威胁。在此，我们提出了一种封装有 ZnIn2S4@UiO-66-NH2（ZnInS/UIO）催化剂的光热增强解毒微针阵列（MNA），用于在模拟阳光（SSL）照射下治疗2-氯乙基硫醚（CEES，SM 类似物）中毒伤口。由于 ZnInS/UIO 具有出色的光热解毒能力，因此在 SSL 照射下可显著提高 CEES 的转化率。将 ZnInS/UIO 催化剂包裹在聚乙烯醇（PVA）MNA 中并刺入皮肤后，催化剂可迅速从 MNA 中释放出来进行解毒。将生成的 ZnInS/UIO-MNA 应用于 CEES 中毒的伤口床后，可以证实伤口愈合过程加快，炎症反应减轻。总之，ZnInS/UIO-MNA 具有令人鼓舞的潜力，可作为战场上 CEES 中毒伤口愈合和恐怖主义行为相关伤害的急救敷料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Materials & Design Engineering-Mechanical Engineering

CiteScore

14.30

自引率

7.10%

发文量

1028

审稿时长

85 days

期刊介绍： Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry. The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.