Tetralactam macrocycle based aggregation-induced emission dots for selective detection of Fe3+ in water and drugs

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED Dyes and Pigments Pub Date : 2024-09-13 DOI:10.1016/j.dyepig.2024.112456

Jian Qin , Peng-Xiang Yuan , Ze-Ping Xiao , Rong Hu , Liu-Pan Yang , Huan Yao , Li-Li Wang

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Abstract

Iron ion (Fe³⁺) is crucial for both biological organisms and the environment, and iron dyshomeostasis can lead to a variety of diseases and environmental issues. Therefore, the detection of Fe³⁺ is of significant importance across various fields. For this purpose, through the co-assembly of water-soluble tetralactam macrocycle H and 1,1,2,2-tetraphenylethylene (TPE), we prepared a new type of tetralactam macrocycle based aggregation-induced emission dots (AIE-dots), namely TPE@H. TPE@H exhibitted good water-solubility and allowed the water-insoluble TPE to aggregate and exhibit strong fluorescence emission in water. Furthermore, the fluorescence of TPE@H could be quenched by Fe³⁺ through the inner filter effect, making TPE@H a potential “turn-off” fluorescent probe for Fe³⁺ detection. TPE@H exhibited a limit of detection as low as 1 μM with high selectivity, and also retained good detection performance in domestic water, human serum, and even drugs, indicating its great potential for biological and environmental monitoring of Fe³⁺. This study not only provides a green and efficient method for detecting Fe³⁺, but also expands the approach for application of water-insoluble dyes in the aqueous environment.

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基于聚合诱导发射点的四内酰胺大环，用于选择性检测水中和药物中的 Fe3+

铁离子（Fe3+）对生物机体和环境都至关重要，铁失衡会导致各种疾病和环境问题。因此，Fe3+ 的检测在各个领域都具有重要意义。为此，我们通过水溶性四内酰胺大环H和1,1,2,2-四苯基乙烯（TPE）的共组装，制备了一种新型的基于四内酰胺大环的聚集诱导发射点（AIE-dots），即TPE@H。TPE@H 具有良好的水溶性，可使不溶于水的 TPE 在水中聚集并发出强烈的荧光。此外，TPE@H 的荧光可通过内滤光片效应被 Fe3+ 熄灭，从而使 TPE@H 成为一种潜在的用于检测 Fe3+ 的 "熄灭 "荧光探针。TPE@H 的检出限低至 1 μM，且具有高选择性，在生活用水、人体血清甚至药物中都能保持良好的检测性能，这表明它在生物和环境监测 Fe3+ 方面具有巨大的潜力。这项研究不仅为检测 Fe3+ 提供了一种绿色、高效的方法，而且拓展了水不溶性染料在水环境中的应用途径。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.