Polyoxometalates emerging as multifunctional powerhouses in the battle against cancer

IF 20.3 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR Coordination Chemistry Reviews Pub Date : 2024-09-16 DOI:10.1016/j.ccr.2024.216210

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Abstract

A variety of emerging anticancer therapeutic strategies, including chemodynamic, photothermal and combination therapies, are igniting considerable interests due to their precise targetability, minimal side effects, high efficacy and simplified treatment procedures. Polyoxometalates (POMs), as typical metallodrugs, offer many advantages in cancer treatment, including simple synthesis processes, a defined and tunable structure, reversible redox properties, photo-thermal conversion capabilities, and acid-responsive aggregation features. This review focus on the application of POM-based therapeutic agents for cancer treatment. An overview of the broad applications of POM- based agents in chemotherapy, chemodynamic therapy, photothermal therapy and different combination therapies is provided, and insights into the corresponding mechanisms are elucidated. The interactions between POM-based materials and substrates in the tumor microenvironment are described in detail. Aiming at accelerating the practical applications of POMs-based anticancer agents, current challenges and the future directions are discussed.

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聚氧化金属酸盐成为抗击癌症的多功能动力源

各种新兴的抗癌治疗策略，包括化学动力疗法、光热疗法和综合疗法，因其精确的靶向性、最小的副作用、高疗效和简化的治疗程序而备受关注。聚氧化金属盐（POMs）作为典型的金属药物，在癌症治疗中具有许多优势，包括简单的合成过程、确定和可调的结构、可逆氧化还原特性、光热转换能力以及酸响应聚集特性。本综述重点介绍基于 POM 的治疗剂在癌症治疗中的应用。综述了基于 POM 的药剂在化疗、化学动力疗法、光热疗法和不同联合疗法中的广泛应用，并阐明了相应的机理。此外，还详细介绍了肿瘤微环境中基于 POM 的材料与基质之间的相互作用。为了加速基于 POMs 的抗癌剂的实际应用，还讨论了当前的挑战和未来的发展方向。

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来源期刊

Coordination Chemistry Reviews 化学-无机化学与核化学

CiteScore

34.30

自引率

5.30%

发文量

457

审稿时长

54 days

期刊介绍： Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers. The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.