Front Cover: Effects of Clinical Mutations in the Second Coordination Sphere and Remote Regions on the Catalytic Mechanism of Non-Heme Fe(II)/2-Oxoglutarate-Dependent Aspartyl Hydroxylase AspH (ChemPhysChem 18/2024)

IF 2.3 3区 化学 Q3 CHEMISTRY, PHYSICAL Chemphyschem Pub Date : 2024-09-16 DOI:10.1002/cphc.202481801
Anandhu Krishnan, Sodiq O. Waheed, Sreerag Melayikandy, Ciara LaRouche, Meredith Paik, Christopher J. Schofield, Tatyana G. Karabencheva-Christova
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Abstract

The Front Cover illustrates how clinically significant mutations in the second coordination sphere and distal regions in the non-heme FeII and 2-oxoglutarate-dependent enzyme AspH influence substrate binding, and ultimately affect the reaction mechanism. More information can be found in the Research Article by T. G. Karabencheva-Christova and co-workers (DOI: 10.1002/cphc.202400303). Image by Sarah Atkinson, Anandhu Krishnan, and Tatyana Karabencheva-Christova.

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封面:第二配位层和偏远区域的临床突变对非血红素 Fe(II)/2-Oxoglutarate 依赖性天冬氨酰羟化酶 AspH 催化机理的影响(ChemPhysChem 18/2024)
封面说明了非血红素 FeII 和 2-氧代戊二酸依赖性酶 AspH 的第二配位层和远端区域中具有临床意义的突变是如何影响底物结合并最终影响反应机制的。更多信息请参阅 T. G. Karabencheva-Christova 及其合作者的研究文章(DOI: 10.1002/cphc.202400303)。图片由 Sarah Atkinson、Anandhu Krishnan 和 Tatyana Karabencheva-Christova 提供。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chemphyschem
Chemphyschem 化学-物理:原子、分子和化学物理
CiteScore
4.60
自引率
3.40%
发文量
425
审稿时长
1.1 months
期刊介绍: ChemPhysChem is one of the leading chemistry/physics interdisciplinary journals (ISI Impact Factor 2018: 3.077) for physical chemistry and chemical physics. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemPhysChem is an international source for important primary and critical secondary information across the whole field of physical chemistry and chemical physics. It integrates this wide and flourishing field ranging from Solid State and Soft-Matter Research, Electro- and Photochemistry, Femtochemistry and Nanotechnology, Complex Systems, Single-Molecule Research, Clusters and Colloids, Catalysis and Surface Science, Biophysics and Physical Biochemistry, Atmospheric and Environmental Chemistry, and many more topics. ChemPhysChem is peer-reviewed.
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